顶空气相色谱-质谱联用技术的应用进展

doi:10.3724/SP.J.1123.2018.05013

摘要/Abstract

摘要：

顶空分析作为一种无有机溶剂萃取的样品处理技术，通常与气相色谱-质谱（GC-MS）技术结合用来分析复杂基质中的挥发性有机物。顶空气相色谱-质谱（HS-GC-MS）技术具有快速、高效、环保、灵敏度高等特点，在常规分析中发挥着重要作用。该文简要概述了静态顶空、动态顶空、顶空固相微萃取分析以及GC-MS联用技术，并介绍了整个顶空分析系统的影响因素和优化过程。根据基质类型的分类，综述了HS-GC-MS在食品和饮料、环境、生物等样品中的应用实例。HS-GC-MS的研究非常活跃，不断出现新应用，在分析挥发性有机物方面具有广阔前景。

关键词: 顶空固相微萃取, 动态顶空, 挥发性有机物, 静态顶空, 气相色谱-质谱, 综述

Abstract:

As a sample preparation technique without extraction by organic solvent, headspace analysis is usually combined with gas chromatography-mass spectrometry (GC-MS) to analyze volatile organic compounds in complex matrices. Headspace gas chromatography-mass spectrometry (HS-GC-MS) is a fast, efficient, green, and sensitive technique, and thus it plays an important role in routine analysis. A brief overview of static headspace, dynamic headspace, headspace solid-phase microextraction and GC-MS is provided, followed by the impact of the analysis system and the optimization process. According to the matrix type classification, the application of HS-GC-MS in the analysis of food samples, environment samples, biology samples, etc. is reviewed. This report clearly indicates that the ongoing research on HS-GC-MS is active and new applications are emerging. It has significant prospects for the analysis of volatile organic compounds.

Key words: dynamic headspace (D-HS), gas chromatography-mass spectrometry (GC-MS), headspace solid-phase microextraction (HS-SPME), review, static headspace (S-HS), volatile organic compounds (VOCs)

中图分类号:

O658

张茜, 刘炜伦, 路亚楠, 吕运开. 顶空气相色谱-质谱联用技术的应用进展[J]. 色谱, 2018, 36(10): 962-971.

ZHANG Xi, LIU Weilun, LU Ya'nan, LÜ Yunkai. Recent advances in the application of headspace gas chromatography-mass spectrometry[J]. Chinese Journal of Chromatography, 2018, 36(10): 962-971.

参考文献

[1] Xu W, Wang X, Cai Z. Anal Chim Acta, 2013, 790:1
[2] Romanik G, Gilgenast E, Przyjazny A, et al. J Biochem Bioph Methods, 2007, 70(2):253
[3] Wang Y H. Environmental Monitoring in China, 2006, 22(2):7 王永华. 中国环境监测, 2006, 22(2):7
[4] Wang Y W, Mccaffrey J, Norwood D L. J Liq Chromatogr Related Technol, 2008, 31(11/12):1823
[5] Chai X S, Fu S Y, Mo S H, et al. Process in Chemistry, 2008, 20(5):762 柴欣生, 付时雨, 莫淑欢, 等. 化学进展, 2008, 20(5):762
[6] Harger R N, Bridwell E G, Raney B B. J Biol Chem, 1939:128
[7] Snow N H, Bullock G P. J Chromatogr A, 2010, 1217(16):2726
[8] Kolb B, Ettre L S. Static Headspace-Gas Chromatography:Theory and Practice. New York:Wiley-VCH, 1997
[9] Ioffe B V, Vitenberg A G. Head-Space Analysis and Related Methods in Gas Chromatography. New York:John Wiley & Sons, 1984
[10] Kolb B. Applied Headspace Gas Chromatography. London:Heyden, 1980
[11] Ettre L S. Headspace Analysis of Food and Flavors:Theory and Practice. New York:Kluwer Academic Plenum Publishers, 2001
[12] Kolb B. J Chromatogr A, 1999, 842:163
[13] Snow N H, Slack G C. TrAC-Trends Anal Chem, 2002, 21(9):608
[14] Zhang Z Y, Pawliszyn J. Anal Chem, 1993, 65(14):1843
[15] Carvalho L M, Carvalho F, Bastos M D L, et al. Talanta, 2014, 118:292
[16] Sramkova I, Horstkotte B, Solich P, et al. Anal Chim Acta, 2014, 828:53
[17] Wang H Y, Guo Y L, Zhang Z X, et al. Analysis and Testing Technology and Instruments, 2003, 9(3):129 王昊阳, 郭寅龙, 张正行, 等. 分析测试技术与仪器, 2003, 9(3):129
[18] Hoh E, Mastovska K. J Chromatogr A, 2008, 1186:2
[19] Helms H, Felix U. LaborPraxis, 2004, 28:46
[20] Zlatkis A, Lichtenstien H, Tishbee A. Chromatographia, 1973, 6(2):67
[21] Liang H C. Method of Gas Chromatography for Trace Analysis. Beijing:China Petrochemical Press, 2000:129 梁汉昌. 痕量物质分析气相色谱法. 北京:中国石化出版社, 2000:129
[22] Guo W, Wang S Y. Food and Drug, 2007, 9(10):47 郭威, 王少云. 食品与药品, 2007, 9(10):47
[23] Bertuzzi A S, McSweeney P L H, Rea M C, et al. Compr Rev Food Sci F, 2018, 17(2):371
[24] Feng J J, Qiu H D, Liu X, et al. TrAC-Trends Anal Chem, 2013, 46:44
[25] Dietz C, Sanz J, Camara C. J Chromatogr A, 2006, 1103(2):183
[26] Aziz-Zanjani M O, Mehdinia A. Anal Chem Acta, 2013, 781:1
[27] Aziz-Zanjani M O, Mehdinia A. Microchim Acta, 2014, 181(11/12):1169
[28] Luo J, Wu Y, Lin S. Am J Nano Res Appl, 2015, 3(1):23
[29] Hou X D, Wang L C, Guo Y. Chem Lett, 2017, 46(10):1444
[30] Holmes G C, Morrell F A. Appl Spectrosc, 1957, 11(2):86
[31] Hernandez F, Sancho J V, Ibanez M, et al. Anal Bioanal Chem, 2012, 403(5):1251
[32] Hernandez F, Portoles T, Pitarch, E, et al. TrAC-Trends Anal Chem, 2011, 30(2):388
[33] Peterson A C, Hauschild J P, Quarmby S T, et al. Anal Chem, 2014, 86(20):10036
[34] Peterson A C, Balloon A J, Westphall M S, et al. Anal Chem, 2014, 86(20):10044
[35] Bowers M T, Taylor S. Int J Mass Spectrom, 2017, 422:146
[36] Neuland M B, Grimaudo V, Mezger K, et al. Meas Sci Technol, 2016, 27(3):1
[37] Syms R R A, Wright S J. Micromech Microeng, 2016, 26(2):1
[38] Hassig M, Altwegg K, Berthelier J J, et al. Planet Space Sci, 2015, 105:175
[39] Dong M, Cheng Y J, Sun W J, et al. Meas Sci Technol, 2017, 28(12):1
[40] Guler Z, Karaca F, Yetisir H, et al. Int J Food Prop, 2013, 16(1):168
[41] Zhao J, Boatright W L. Food Chem, 2017, 221:345
[42] Jeong E J, Lee S H, Kim B T, et al. Food Sci Biotechnol, 2017, 26(2):363
[43] Shen M Y, Liu Q, Jia H B, et al. LWT-Food Sci Technol, 2016, 72:44
[44] Pugajeva I, Rozentale I, Viksna A, et al. Food Chem, 2016, 212:20
[45] Cardador M J, Gallego M. J Chromatogr A, 2016, 1454:9
[46] Cardador M J, Fernandez-Salguero J, Gallego M. J Chromatogr A, 2015, 1408:22
[47] Serrano M, Gallego M, Silva M. J Chromatogr A, 2017, 1524:21
[48] Cardador M J, Gallego M. J Chromatogr A, 2017, 1509:9
[49] Sanjuan-Herraez D, Lliso I, Pastor A, et al. Talanta, 2012, 98:40
[50] Sanjuan-Herraez D, de la Osa S, Pastor A, et al. Microchem J, 2014, 114:42
[51] Yilmazcan O, Ozer E T, Izgi B, et al. Ekoloji, 2013, 22(89):76
[52] Pavon J L P, Ferreira A M C, Laespada M E F, et al. J Chromatogr A, 2009, 1216:6728
[53] Pavon J L P, Sanchez M D N, Laespada M E F, et al. J Chromatogr A, 2007, 1175:106
[54] Cai Y, Yan Z H, Wang L J, et al. J Chromatogr A, 2016, 1429:97
[55] Finnegan C, Ryan D, Enright A M, et al. Molecules, 2018, 23(3):627
[56] de la Torre M P D, Priego-Capote F, de Castro M D L. Anal Methods, 2015, 7(5):1758
[57] Alcudia-Leon M D, Lucena R, Cardenas S, et al. Anal Bioanal Chem, 2015, 407(3):795
[58] Eberl A, Altendorfer-Kroath T, Kollmann D, et al. Anal Biochem, 2016, 509:130
[59] Ganguly S, Mahanty A, Mitra T, et al. J Food Process Preserv, 2017, 41(6):1
[60] Serrano M, Gallego M, Silva M. J Chromatogr A, 2016, 1437:241
[61] Anton A P, Ferreira A M C, Pinto C G, et al. J Chromatogr A, 2014, 1367:9
[62] Paredes R M G, Pinto C G, Pavon J L P, et al. J Sep Sci, 2016, 39(17):3375
[63] Paredes R M G, Pinto C G, Pavon J L P, et al. Anal Methods, 2017, 9(39):5784
[64] Xiao H T, He L, Tong R S, et al. J Clin Lab Anal, 2014, 28(5):386
[65] Giuliani N, Saugy M, Augsburger M, et al. Talanta, 2015, 144:196
[66] Varlet V, Smith F, Augsburger M. J Chromatogr B, 2013, 913:155
[67] Smith F, Augsburger M, Varlet V. J Anal Toxicol, 2014, 38(2):73
[68] Ohno H, Mutsuga M, Kawamura Y. J AOAC Int, 2014, 97(5):1452
[69] Lee S, Pyo H, Chung B C, et al. Bull Korean Chem Soc, 2014, 35(11):3280
[70] Zhang J D, Cao G, Xia Y H, et al. Pharmacogn Mag, 2014, 10(39):249
[71] Ochiai N, Tsunokawa J, Sasamoto K, et al. J Chromatogr A, 2014, 1371:65
[72] Ochiai N, Sasamoto A, Hoffmann K, et al. J Chromatogr A, 2012, 1240:59
[73] Ochiai N, Sasamoto K, Tsunokawa J, et al. J Chromatogr A, 2015, 1421:103
[74] Ha J, Wang Y, Jang H, et al. Food Chem, 2014, 142:79
[75] Wang Y, Ha J. J Chromatogr Sci, 2013, 51(5):446
[76] Agelopoulos N G, Pickett J A. J Chem Ecol, 1998, 21:1161
[77] Huang D H, Zhang Z G, Chen G P, et al. Chinese Journal of Chromatography, 2015, 33(3):318 黄代红, 张振国, 陈国平, 等. 色谱, 2015, 33(3):318
[78] Montero D A, Marques M O, Meletti L M, et al. An Acad Bras Cienc, 2016, 88(3):1191
[79] Sonmezdag A S, Kelebek H, Selli S. Foods, 2017, 6(2):1
[80] Durenne B, Blondel A, Druart P, et al. Phytochem Analysis, 2018:1
[81] Rodriguez S A, Paliza M L, Nazareno M A. Aust J Chem, 2017, 70(8):902
[82] Magnusson R, Nordlander T, Ostin A. J Chromatogr A, 2016, 1429:40
[83] Boczkaj G, Mako P, Przyjazny A. Anal Methods, 2016, 8:3570
[84] Horii Y, Minomo K, Ohtsuka N, et al. Sci Total Environ, 2017, 586:56
[85] Christensen P, Dela Cruz M, Tomasi G, et al. LC GC Europe, 2018, 31(4):190
[86] Feng X Y, Wang D, Liu M, et al. Food Industry, 2016, 37(9):171 冯小雨, 王丹, 刘敏, 等. 食品工业, 2016, 37(9):171
[87] Hao F L, Fan Y, Yan S, et al. Modern Food Science and Technology, 2018, 34(3):203 郝飞龙, 范莹, 延莎, 等. 现代食品科技, 2018, 34(3):203
[88] Liu J K, Zhao W, Li S H, et al. Molecules, 2018, 23(2):462
[89] Slaghenaufi D, Tonidandel L, Moser S, et al. Food Anal Method, 2017, 10(11):3706
[90] Liu J K, Zhang A X, Li S H, et al. Chinese Journal of Chromatography, 2017, 35(11):1184 刘敬科, 张爱霞, 李少辉, 等. 色谱, 2017, 35(11):1184
[91] Arcari S G, Caliari V, Sganzerla M, et al. Talanta, 2017, 174:752
[92] Stoj A, Czernecki T, Domagala D, et al. Int J Food Prop, 2017, 20(S1):S830
[93] Shi Y F, Di T M, Yang S L, et al. Food Science, 2018, 39(8):167 石渝凤, 邸太妹, 杨绍兰, 等. 食品科学, 2018, 39(8):167
[94] Liu C, Zhang W J, Yan L, et al. Food Science and Technology, 2018, 39(8):167 刘聪, 张文杰, 严亮, 等. 食品科技, 2018, 39(8):167
[95] Ma L J, Qiao Y, Du L P, et al. Food Anal Method, 2017, 10(7):2481
[96] Wang C, Zhang C X, Kong Y W, et al. Food Res Int, 2017, 100:267
[97] Wu Y S, Lv S D, Lian M, et al. CyTA-J Food, 2016, 14(3):423
[98] He C J, Guo X M, Yang Y M, et al. Anal Methods, 2016, 8(23):4727
[99] Wang L L, Zhang Y G, Yang J G, et al. Acta Tea Sinica, 2017, 58(1):1 王丽丽, 张应根, 杨军国, 等. 茶叶学报, 2017, 58(1):1
[100] Yang Y Q, Yin H X, Yuan H B, et al. PLoS One, 2018, 13(3):1
[101] Hu X Z, Peng X T, Zhou Y X, et al. China Measurement & Test, 2017, 43(2):55 胡西洲, 彭西甜, 周有祥, 等. 中国测试, 2017, 43(2):55
[102] Hu X Z, Peng X T, Zhou Y X, et al. Journal of Analytical Science, 2017, 33(3):352 胡西洲, 彭西甜, 周有祥, 等. 分析科学学报, 2017, 33(3):352
[103] Zheng M, Huang X B, Peng Z, et al. Chinese Journal of Tropical Crops, 2017, 38(4):758 郑敏, 黄晓兵, 彭政, 等. 热带作物学报, 2017, 38(4):758
[104] Xu Z Q, Zhang X Y, Xu H S, et al. Chemical Analysis and Meterage, 2017, 26(2):48 徐振秋, 张晓赟, 徐恒省, 等. 化学分析计量, 2017, 26(2):48
[105] Zhou Y, Wu J, Zhong F, et al. Environmental Science & Technology, 2016, 39(10):92 周洋, 吴娟, 钟非, 等. 环境科学与技术, 2016, 39(10):92
[106] Cheng J G, Liu K Y, Bai M D, et al. Chinese Journal of Chromatography, 2015, 33(12):128 成建国, 刘开颖, 白敏冬, 等. 色谱, 2015, 33(12):128
[107] Dominguez I, Arrebola F J, Gavara R, et al. Anal Chim Acta, 2018, 1002:39
[108] Kang H I, Shin H S. J Chromatogr A, 2016, 1448:115
[109] Zhang Y M, Zhao D, Wang B, et al. Instrum Sci Technol, 2015, 43(3):344
[110] Yang C T, Lian H X, Lin Q, et al. China Water & Wastewater, 2017, 33(18):132 杨创涛, 练海贤, 林青, 等. 中国给水排水, 2017, 33(18):132
[111] George M J, Marjanovic L, Williams D B G, et al. Anal Chem, 2015, 87(19):9559
[112] Xi Y, Zhan M. Physical Testing and Chemical Analysis(Part B:Chemical Analysis), 2014, 50(6):775 奚晔, 詹铭. 理化检验(化学分册), 2014, 50(6):775
[113] Zhang J K, Gu Q Q, Xu X Y, et al. China Water & Wastewater, 2015, 31(21):138 张泾凯, 顾青清, 许小燕, 等. 中国给水排水, 2015, 31(21):138
[114] Tan L, Zhang W B, Xu X Y, et al. Environmental Chemistry, 2017, 36(7):168 谭丽, 张文斌, 许秀艳, 等. 环境化学, 2017, 36(7):1681
[115] Zhang C H, Zheng Y H, Ge Y, et al. Chinese Journal of Analysis Laboratory, 2016, 35(9):1024 张春华, 郑燕恒, 葛滢, 等. 分析实验室, 2016, 35(9):1024
[116] Tan L, Xu X Y, Chen Y, et al. Physical Testing and Chemical Analysis (Part B:Chemical Analysis), 2015, 51(10):1451 谭丽, 许秀艳, 陈烨, 等. 理化检验(化学分册), 2015, 51(10):1451
[117] Oh J A, Shin H S. Anal Chim Acta, 2017, 950:57
[118] Pang L, Yang P L, Pang R, et al. Int J Environ An Ch, 2017, 97(11):1094
[119] Trujillo-Rodriguez M J, Nan H, Anderson J L. J Chromatogr A, 2018, 1540:11
[120] Wasielewska M, Zygmunt B, Anderson J L. Chromatographia, 2014, 77(1/2):151
[121] Cai C C, Zhang P C, Deng J L, et al. J Sep Sci, 2018, 41(5):1104
[122] Zhang H X, Zhang X, Chang Q Y, et al. J Sep Sci, 2016, 39(14):2770
[123] Liu Y L, Chen X F, Wang X, et al. J Sep Sci, 2014, 37(12):1496
[124] Silva C A, Madureira L A S. J Braz Chem Soc, 2015, 26(4):676
[125] Masoum S, Gholami A, Ghaheri S, et al. J Sep Sci, 2016, 39(14):2760
[126] Vallarino J G, Erban A, Fehrle I, et al. Methods Mol Biol, 2018, 1778:225
[127] Jerkovic I, Marijanovic Z, Roje M, et al. PLoS One, 2018, 13(5):1
[128] Wu Y B, Yan Z M, Zhao J J, et al. Trop J Pharm Res, 2016, 15(10):2241
[129] Yuan R Y, Li S S, Zheng X C, et al. Anal Lett, 2014, 47(9):1541