色谱 ›› 2019, Vol. 37 ›› Issue (5): 471-476.DOI: 10.3724/SP.J.1123.2018.12019

• 专论与综述 • 上一篇    下一篇

蛋白质组学在人乳蛋白质研究中的应用

于文皓1,2, 祁艳霞1, 靳艳2   

  1. 1. 大连海洋大学食品科学与工程学院, 辽宁 大连 116023;
    2. 中国科学院大连化学物理研究所, 中国科学院分离分析化学重点实验室, 辽宁 大连 116023
  • 收稿日期:2018-12-12 出版日期:2019-05-08 发布日期:2015-03-23
  • 通讯作者: 祁艳霞,Tel:(0411)84763107,E-mail:qiyanxia@dlou.edu.cn;靳艳,Tel:(0411)84379576,E-mail:yanjin@dicp.ac.cn
  • 基金资助:

    国家重点研发计划项目(2018YFC0910302);国家自然科学基金青-科学基金项目(31601538).

Investigation of human milk proteins by proteomics

YU Wenhao1,2, QI Yanxia1, JIN Yan2   

  1. 1. College of Food Science and Engineering, Dalian Ocean University, Dalian 116023, China;
    2. CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical and Physics, Chinese Academy of Sciences, Dalian 116023, China
  • Received:2018-12-12 Online:2019-05-08 Published:2015-03-23
  • Supported by:

    National Key Research and Development Program of China (No. 2018YFC0910302); National Natural Science Foundation of China (No. 31601538).

摘要:

人乳是新生儿最理想的天然食物,蛋白质是人乳中最主要的营养成分之一。随着蛋白质组学技术的发展,利用蛋白质组学的方法研究人乳蛋白质也取得了一些研究成果。本文综述了近年来蛋白质组学技术在人乳蛋白质研究中的应用,分别从人乳蛋白质的组成研究、动态变化、人乳与其他来源乳汁的蛋白质差异比较、人乳磷酸化蛋白和糖基化蛋白研究、人乳内源肽的研究及人乳蛋白与疾病等几个方面进行了阐述。蛋白质组学技术使人乳蛋白质的研究进入了微量营养研究的时代,人乳蛋白质组学的研究成果将为母婴健康提供更好的保障。

关键词: 蛋白质, 蛋白质组学, 人乳, 肽, 综述

Abstract:

Human milk is the optimal food for infant nutrition and growth. Proteins are abundant and represent a key element in human milk. With recent developments in proteomics, more tools are available to explore human milk proteins. This article aims to review the recent investigations of human milk proteins using proteomic methodologies. This review focuses on using proteomics as a tool to study the components of human milk proteins; dynamics of human milk proteins during lactation; comparison of proteome from human milk and other source milk, phosphoprotein and glycoprotein analysis of human milk; endogenous peptides in human milk; and the human milk proteome and its correlation to curing of various diseases. Proteomics technology has enabled the study of human milk proteins in the era of micronutrient research, and the results of these studies will be helpful for further analysis of mother and infant health.

Key words: human milk, peptide, protein, proteomics, review

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