色谱 ›› 2019, Vol. 37 ›› Issue (2): 132-142.DOI: 10.3724/SP.J.1123.2018.11025

• 专论与综述 • 上一篇    下一篇

纳流液相分离与电感耦合等离子体质谱联用技术研究新进展

丁芳芳1,2, 朱珏1, 郭睿1, 张博1   

  1. 1. 厦门大学化学化工学院, 福建 厦门 361005;
    2. 浙江省食品药品检验研究院, 浙江 杭州 310051
  • 收稿日期:2018-11-22 出版日期:2019-02-09 发布日期:2014-12-31
  • 通讯作者: 张博,Tel:(0592)2188691,E-mail:bozhang@xmu.edu.cn
  • 基金资助:

    国家自然科学基金(21475110,21535007,J1310024);厦门市科技计划项目(3502Z20173019);中央高校基本科研业务费(20720160051).

Recent advances in hyphenation of nanoflow liquid phase separation with inductively coupled plasma mass spectrometry

DING Fangfang1,2, ZHU Jue1, GUO Rui1, ZHANG Bo1   

  1. 1. College of Chemistry & Chemical Engineering, Xiamen University, Xiamen 361005, China;
    2. Zhejiang Institute for Food and Drug Control, Hangzhou 310051, China
  • Received:2018-11-22 Online:2019-02-09 Published:2014-12-31
  • Supported by:

    National Natural Science Foundation of China (Nos. 21475110, 21535007, J1310024); Xiamen Municipal Science and Technology Plan Project (No. 3502Z20173019); Fundamental Research Funds for Central Universities of China (No. 20720160051).

摘要:

高效微纳液相分离技术如纳流液相色谱、毛细管电泳、微芯片色谱/电泳等与电感耦合等离子体质谱(ICP-MS)检测技术联用,既具有前端分离技术高选择性、高灵敏度、快速、低样品消耗的特点,又结合了后端ICP-MS检测分辨率高、动态范围宽、可绝对定量等优势,正在发展成为一种重要的高内涵联用分析手段。该文对近年来纳流液相分离与ICP-MS联用装置的发展作一系统介绍,对其在化学与生物化学分析等领域的应用予以综述,并展望了该联用技术的发展前景。

关键词: 电感耦合等离子体质谱, 接口技术, 纳流液相分离, 液相色谱-质谱联用, 综述

Abstract:

High-performance nanoflow liquid-phase separation techniques such as nanoflow liquid chromatography (nanoLC), capillary electrophoresis (CE), and microchip chromatography and electrophoresis (chip-ICP-MS) have been hyphenated with inductively coupled plasma mass spectrometry (ICP-MS) extensively. This hyphenation combines the excellent characteristics of the front-end separation technology, such as high selectivity, sensitivity, and speed, and low sample consumption, and the advantages of back-end ICP-MS, such as high resolution, wide dynamic range, and absolute quantification capability. Thus, such hyphenation is becoming an increasingly important analytical tool. Herein we systematically introduce the recent development of hyphenated nanoLC, CE, and chip-ICP-MS, review its application in chemical and biochemical analysis, and discuss potential future developments of hyphenating these technologies.

Key words: inductively coupled plasma mass spectrometry (ICP-MS), interface technology, liquid chromatography-mass spectrometry (LC-MS) hyphenation, nanoflow liquid chromatography, review

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