色谱 ›› 2019, Vol. 37 ›› Issue (3): 265-273.DOI: 10.3724/SP.J.1123.2018.10006

• 专论与综述 • 上一篇    下一篇

生物样品中神经递质的定量测定及其应用研究进展

曹雨虹1, 张明勇1, 刘敏2, 洪战英1   

  1. 1. 第二军医大学药学院药物分析学教研室, 上海市药物(中药)代谢产物研究重点实验室, 上海 200433;
    2. 第二军医大学长海医院药学部, 上海 200433
  • 收稿日期:2018-10-08 出版日期:2019-03-08 发布日期:2015-01-21
  • 通讯作者: 洪战英.E-mail:hongzhy001@163.com.
  • 基金资助:

    国家自然科学基金项目(81673386).

Research advancement in the determination of neurotransmitters in biological samples and their applications

CAO Yuhong1, ZHANG Mingyong1, LIU Min2, HONG Zhanying1   

  1. 1. Department of Pharmaceutical Analysis, School of Pharmacy, Second Military Medical University, Shanghai Key Laboratory for Pharmaceutical(Chinese Materia Medica) Metabolites Research, Shanghai 200433, China;
    2. Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
  • Received:2018-10-08 Online:2019-03-08 Published:2015-01-21
  • Supported by:

    National Natural Science Foundation of China (No. 81673386).

摘要:

神经递质(NTs)是神经传递的内源性化学信使,在大脑功能中发挥重要作用。中枢神经系统中神经递质浓度的变化与许多精神和生理疾病有关。神经递质的测定已成为疾病诊断和监测以及治疗干预的重要手段,有效的神经递质体内监测对于疾病诊疗乃至新药研发都至关重要。该文就近年来神经递质的检测方法,包括仪器检测法、电化学检测法以及一些新型检测方法等进行综述,并总结了目前神经递质检测在一些疾病研究中的应用进展。

关键词: 阿尔茨海默症, 定量检测, 神经递质, 液相色谱-质谱联用, 综述

Abstract:

Neurotransmitters (NTs) are endogenous chemical messengers that are involved in nerve signal transmission and play important roles in brain function. Changes in NT concentrations in the central nervous system are related to many mental and physiological illnesses. The determination of various NTs has become important in disease diagnosis, monitoring, and treatment interventions. Effective monitoring of NTs in vivo is essential for disease diagnosis and treatment as well as for the research and development of new drugs. This article provides a review of the methods used in NT detection in recent years, including instrumental and electrochemical techniques as well as some new detection methods, and summarizes the applications of the methods for NT detection in some diseases.

Key words: Alzheimer disease (AD), liquid chromatography-mass spectrometry (LC-MS), neurotransmitters (NTs), quantitative detection, review

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