色谱

色谱

• 中药质量控制专栏 • 上一篇    下一篇

色谱指纹图谱在中药质量控制中的应用

周建良,齐炼文,李萍

  

  1. Key Laboratory of Modern Chinese Medicines, Ministry of Education, Department of Pharmacognosy,
    China Pharmaceutical University, Nanjing 210009, China
  • 收稿日期:2007-11-02 修回日期:1900-01-01 出版日期:2008-03-30 发布日期:1984-06-25
  • 通讯作者: 李萍

Quality control of Chinese herbal medicines with chromatographic fingerprints

ZHOU Jianliang, QI Lianwen, LI Ping

  

  1. Key Laboratory of Modern Chinese Medicines, Ministry of Education, Department of Pharmacognosy,
    China Pharmaceutical University, Nanjing 210009, China
  • Received:2007-11-02 Revised:1900-01-01 Online:2008-03-30 Published:1984-06-25

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摘要：

介绍了色谱指纹图谱在中药质量控制体系,即中药真实性鉴定(化学指纹图谱)、有效性评价(谱效学、生物指纹图谱、代谢指纹图谱)以及安全性评价方面的应用。目前化学指纹图谱在中药的真实性鉴定方面已比较成熟;谱效学、生物指纹图谱和代谢指纹图谱由于与药效活性相关,在中药的有效性评价中已体现出优势;色谱指纹图谱在中药的安全性评价方面的应用也愈来愈受到重视。

关键词: 安全性评价, 代谢指纹图谱, 谱效学, 色谱指纹图谱, 生物指纹图谱, 有效性评价, 真实性鉴定, 中药

Abstract:

The applications of chromatographic fingerprint in the quality control of Chinese herbal medicines (CHMs), such as chemical fingerprint in the authentication of CHMs, chromatographic pharmacodynamics, biofingerprint and metabolic fingerprint in the efficacy evaluation of CHMs are reviewed. In recent quality control system of CHMs, chemical fingerprint has been a forceful technology in the authentication of CHMs, and chromatographic pharmacodynamics, biofingerprint and metabolic fingerprint have shown advantages in the efficacy evaluation of CHMs because of their correlations with pharmacological activities. Furthermore, the application of chromatographic fingerprint in safety evaluation of CHMs becomes more and more significant.

Key words: authentication, biofingerprint, Chinese herbal medicines （CHMs） , chromatographic pharmacodynamics, efficacy evaluation, metabolic fingerprint, safety evaluation, chromatographic fingerprint