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微流控芯片毛细管电泳在蛋白质分离分析中的应用研究进展

董娅妮，方群

  

  1. Institute of Microanalytical Systems, Zhejiang University, Hangzhou 310058, China
  • 收稿日期:2008-02-19 修回日期:2008-04-16 出版日期:2008-05-30 发布日期:1984-03-25
  • 通讯作者: 方群

Developments of microfluidic chip-based capillary electrophoresis for protein separation

DONG Yani, FANG Qun

  

  1. Institute of Microanalytical Systems, Zhejiang University, Hangzhou 310058, China
  • Received:2008-02-19 Revised:2008-04-16 Online:2008-05-30 Published:1984-03-25
  • Contact: Fang Qun

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摘要：

重点介绍了近年来国内外在微流控芯片毛细管电泳法用于蛋白质分离分析方面的研究进展。按照分离模式的不同，综述了各种应用于蛋白质分离的微流控芯片毛细管电泳系统，讨论了抑制芯片中的蛋白吸附的各种方法，并展望了芯片毛细管电泳系统在蛋白质分离领域的发展前景。引用文献47篇。

关键词: 蛋白质分离, 毛细管电泳, 微流控芯片, 综述

Abstract:

In this paper, the developments of microfluidic chip-based capillary electrophoresis (CE) for protein separation in recent years are reviewed. Various chip-based CE systems for protein separation based on different CE separation modes are introduced. The approaches to suppress the adsorption of proteins on the surface of microchannel on chips are discussed. The application prospect for chip-based CE in protein separation is also proposed. Forty-seven references are cited.

Key words: capillary electrophoresis （CE）, protein separation, review , microfluidic chip