色谱 ›› 2015, Vol. 33 ›› Issue (4): 334-341.DOI: 10.3724/SP.J.1123.2014.12041

• 专论与综述 • 上一篇    下一篇

涂层技术在毛细管电泳手性分离中的应用

王丙香1, 柴微波1, 唐安娜2, 丁国生1   

  1. 1. 天津大学药物科学与技术学院, 天津 300072;
    2. 南开大学化学学院分析科学研究中心, 天津 300071
  • 收稿日期:2014-12-30 修回日期:2015-02-05 出版日期:2015-04-08 发布日期:2015-03-30
  • 通讯作者: 丁国生
  • 基金资助:

    国家自然科学基金项目(21005054,21275081).

Application of coating technology in capillary electrophoresis for chiral separation

WANG Bingxiang1, CHAI Weibo1, TANG Anna2, DING Guosheng1   

  1. 1. School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China;
    2. Research Center for Analytical Sciences, College of Chemistry, Nankai University, Tianjin 300071, China
  • Received:2014-12-30 Revised:2015-02-05 Online:2015-04-08 Published:2015-03-30

摘要:

手性是自然界的本质属性之一。手性分离分析技术对生命科学、环境科学、生物工程和药物工程等许多学科都具有十分重要的意义。当前,对不同种类手性化合物进行拆分已成为毛细管电泳技术最具特色的研究和应用领域之一。然而,被分析物(或拆分剂)在毛细管内壁的吸附是毛细管电泳手性分离中的常见问题。涂层技术就是采用不同的方法对毛细管内壁进行改性,是抑制非特异性吸附、提高分离效率及分离重现性最简便和最有效的方法。本文主要综述了近十几年来各种涂层技术在毛细管电泳手性分离领域的应用现状,并对毛细管涂层技术今后的发展进行了展望。

关键词: 毛细管电泳, 手性分离, 涂层, 综述

Abstract:

Chirality is one of the intrinsic attributes of the nature. Chiral separation and analysis are of great importance in many research fields, such as life science, environmental science, biological engineering and pharmaceutical engineering. Currently, chiral capillary electrophoresis technique used for the enantioselective resolution of different kinds of racemates has become one of the most distinctive research and application fields. However, the adsorption of the analytes (or chiral selectors) on the inner wall of the capillary is a common problem in capillary electrophoresis chiral separation. Coating technology, namely modification of the inner wall of the capillary, is the simplest and most effective way to suppress disadvantageous adsorption, and to improve the separation efficiency and analysis repeatability. In this review, the recent applications of different coating procedures in chiral analysis are presented, and the future developments in this field are also prospected.

Key words: capillary electrophoresis (CE), chiral separation, coating, review

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