循环肿瘤细胞捕获方法的研究进展

doi:10.3724/SP.J.1123.2018.12016

色谱 ›› 2019, Vol. 37 ›› Issue (4): 358-366.DOI: 10.3724/SP.J.1123.2018.12016

循环肿瘤细胞捕获方法的研究进展

刘路宽^1,2,3, 杨开广¹, 梁振¹, 张丽华¹, 张玉奎¹

1. 中国科学院大连化学物理研究所, 中国科学院分离分析化学重点实验室, 辽宁大连 116023;
2. 中国科学院大学, 北京 100049;
3. 大连理工大学, 精细化工国家重点实验室, 辽宁大连 116024

收稿日期:2018-12-10 出版日期:2019-04-08 发布日期:2015-02-14
通讯作者: 张丽华.Tel:(0411)84379720,E-mail:lihuazhang@dicp.ac.cn
基金资助:
国家重点研发计划（2017YFA0505003，2016YFA0501401）；国家自然科学基金（21575143，91543201，21725506）；中国科学院前沿科学重点研究项目（QYZDY-SSW-SLH017）；中国科学院青-创新促进会（2017222）.

Advances in capture methods of circulating tumor cells

LIU Lukuan^1,2,3, YANG Kaiguang¹, LIANG Zhen¹, ZHANG Lihua¹, ZHANG Yukui¹

1. CAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China;
2. University of Chinese Academy of Sciences, Beijing 100049, China;
3. State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China

Received:2018-12-10 Online:2019-04-08 Published:2015-02-14
Supported by:
National Key Research and Development Program of China (Nos. 2017YFA0505003, 2016YFA0501401); National Natural Science Foundation (Nos. 21575143, 91543201, 21725506); CAS Key Project in Frontier Science (No. QYZDY-SSW-SLH017); Youth Innovation Promotion Association, CAS (No. 2017222).

摘要/Abstract

摘要：

血液中的循环肿瘤细胞（CTCs）携带着肿瘤组织的遗传和表型信息，是液体活检的重要标志物。监测和分析血液中CTCs的数量和性质对癌症的早期诊断、治疗方案的确定和疗效评估具有重要意义。然而CTCs在血液中的含量极低，实现对CTCs的捕获与检测极具挑战。该文综述了基于生物物理原理、生物亲和原理以及人工抗体的CTCs捕获方法，并从捕获效率、捕获纯度和释放活性保持等方面进行了评述。此外，该文还对CTCs捕获方法的发展趋势进行了展望。

关键词: 亲和, 人工抗体, 生物物理, 选择性捕获, 循环肿瘤细胞, 综述

Abstract:

Since circulating tumor cells (CTCs) in the blood carry the genetic and phenotypic information of tumor tissues, they are regarded as important markers for liquid biopsy, especially for the early diagnosis of cancer, determination of treatment options and evaluation of prognosis. However, the capture and detection of CTCs is challenging because of their extremely low concentration in blood. In this review, recent advances in capture methods of CTCs based on their biophysical properties, affinity, and artificial antibodies are summarized. The advantages and drawbacks of these methods are discussed from the aspects of capture efficiency, capture purity and maintenance of activity after release. Future trends in CTCs capture are also discussed.

Key words: affinity, artificial antibody, biophysics, circulating tumor cells (CTCs), review, selective capture

中图分类号:

O658

刘路宽, 杨开广, 梁振, 张丽华, 张玉奎. 循环肿瘤细胞捕获方法的研究进展[J]. 色谱, 2019, 37(4): 358-366.

LIU Lukuan, YANG Kaiguang, LIANG Zhen, ZHANG Lihua, ZHANG Yukui. Advances in capture methods of circulating tumor cells[J]. Chinese Journal of Chromatography, 2019, 37(4): 358-366.

参考文献

[1] Alix-Panabieres C, Pantel K. Nat Rev Cancer, 2014, 14(9):623
[2] Murtaza M, Dawson S J, Pogrebniak K, et al. Nat Commun, 2015, 6:8760
[3] Friedlander T W, Premasekharan G, Paris P L. Pharmacol Ther, 2014, 142(3):271
[4] Wang H Z, Hara Y, Liu X T, et al. Oncotarget, 2015, 6(29):27304
[5] Ferreira M M, Ramani V C, Jeffrey S S. Mol Oncol, 2016, 10(3):374
[6] Hao S J, Wan Y, Xia Y Q, et al. Adv Drug Deliv Rev, 2018, 125:3
[7] Zheng S, Lin H, Liu J Q, et al. J Chromatogr A, 2007, 1162(2):154
[8] Sarioglu A F, Aceto N, Kojic N, et al. Nat Methods, 2015, 12(7):685
[9] Oh A G, Lee D W, Cho Y-H. Sensor Actuat B:Chem, 2012, 166/167:24
[10] Rosenberg R, Gertler R, Friederichs J, et al. Cytometry, 2002, 49(4):150
[11] Di Carlo D. Lab Chip, 2009, 9(21):3038
[12] Lin E, Rivera-Baez L, Fouladdel S, et al. Cell Syst, 2017, 5(3):295
[13] Becker F F, Wang X B, Huang Y, et al. Proc Natl Acad Sci U S A, 1995, 92(3):860
[14] Gupta V, Jafferji I, Garza M, et al. Biomicrofluidics, 2012, 6(2):24133
[15] Shim S, Stemke-Hale K, Tsimberidou A M, et al. Biomicrofluidics, 2013, 7(1):11807
[16] Peeters D J, De Laere B, Van den Eynden G G, et al. Br J Cancer, 2013, 108(6):1358
[17] Manaresi N, Romani A, Medoro G, et al. IEEE J Solid-St Circ, 2003, 38(12):2297
[18] Wu M, Huang P H, Zhang R, et al. Small, 2018, 14(32):e1801131
[19] Galanzha E I, Zharov V P. Cancers, 2013, 5(4):1691
[20] Nedosekin D A, Juratli M A, Sarimollaoglu M, et al. J Biophotonics, 2013, 6(6/7):523
[21] Li P, Mao Z, Peng Z, et al. Proc Natl Acad Sci U S A, 2015, 112(16):4970
[22] Sinkala E, Sollier-Christen E, Renier C, et al. Nat Commun, 2017, 8:14622
[23] Hou S, Zhao H, Zhao L, et al. Adv Mater, 2013, 25(11):1547
[24] Andreopoulou E, Yang L Y, Rangel K M, et al. Int J Cancer, 2012, 130(7):1590
[25] Truini A, Alama A, Dal Bello M G, et al. Front Oncol, 2014, 4:242
[26] Talasaz A H, Powell A A, Huber D E, et al. Proc Natl Acad Sci U S A, 2009, 106(10):3970
[27] Cheng S B, Xie M, Xu J Q, et al. Anal Chem, 2016, 88(13):6773
[28] Sheng W, Ogunwobi O O, Chen T, et al. Lab Chip, 2014, 14(1):89
[29] Bao J J M, Wang D D, Li Y X. Chinese Journal of Chromatography, 2017, 35(1):129 包建民, 王丹丹, 李优鑫. 色谱, 2017, 35(1):129
[30] Du J H, Liu X, Xu X P. Chinese Journal of Chromatography, 2014, 32(1):7 杜晶辉, 刘旭, 徐小平. 色谱, 2014, 32(1):7
[31] Nagrath S, Sequist L V, Maheswaran S, et al. Nature, 2007, 450(7173):1235
[32] Galletti G, Sung M S, Vahdat L T, et al. Lab Chip, 2014, 14(1):147
[33] Kirby B J, Jodari M, Loftus M S, et al. PLoS One, 2012, 7(4):e35976
[34] Stott S L, Hsu C H, Tsukrov D I, et al. Proc Natl Acad Sci U S A, 2010, 107(43):18392
[35] Yu M, Bardia A, Wittner B S, et al. Science, 2013, 339(6119):580
[36] Karabacak N M, Spuhler P S, Fachin F, et al. Nat Protoc, 2014, 9(3):694
[37] Nanus D M, Giannakakou P. Science, 2015, 349(6254):1283
[38] Park M H, Reategui E, Li W, et al. J Am Chem Soc, 2017, 139(7):2741
[39] Dokukin M E, Guz N V, Gaikwad R M, et al. Phys Rev Lett, 2011, 107(2):028101
[40] Bettinger C J, Langer R, Borenstein J T. Angew Chem Int Ed Engl, 2009, 48(30):5406
[41] Nguyen A T, Sathe S R, Yim E K. J Phys Condens Matter, 2016, 28(18):183001
[42] Hsiao Y S, Luo S C, Hou S, et al. Small, 2014, 10(15):3012
[43] Zhang H, Jia Z, Wu C, et al. ACS Appl Mater Interfaces, 2015, 7(36):20477
[44] Saucedo-Zeni N, Mewes S, Niestroj R, et al. Int J Oncol, 2012, 41(4):1241
[45] Li W, Wang J, Ren J, et al. Adv Mater, 2013, 25(46):6737
[46] Wang S, Liu K, Liu J, et al. Angew Chem Int Ed Engl, 2011, 50(13):3084
[47] Yoon H J, Kim T H, Zhang Z, et al. Nat Nanotechnol, 2013, 8(10):735
[48] Ke Z, Lin M, Chen J F, et al. ACS Nano, 2015, 9(1):62
[49] Rahong S, Yasui T, Kaji N, et al. Lab Chip, 2016, 16(7):1126
[50] Zhao Y, Xu D, Tan W. Integr Biol, 2017, 9(3):188
[51] Wan Y, Liu Y, Allen P B, et al. Lab Chip, 2012, 12(22):4693
[52] Zamay G S, Kolovskaya O S, Zamay T N, et al. Mol Ther, 2015, 23(9):1486
[53] Liu L, Yang K, Zhu X, et al. Talanta, 2017, 175 189
[54] Liu G, Mao X, Phillips J A, et al. Anal Chem, 2009, 81(24):10013
[55] Sheng W, Chen T, Kamath R, et al. Anal Chem, 2012, 84(9):4199
[56] Xue L L, Lyu Z L, Luan Y F, et al. Polym Chem, 2015, 6(19):3708
[57] Viraka Nellore B P, Kanchanapally R, Pramanik A, et al. Bioconjug Chem, 2015, 26(2):235
[58] Zheng F Y, Cheng Y, Wang J, et al. Adv Mater, 2014, 26(43):7333
[59] Bai L, Du Y, Peng J, et al. J Mater Chem B, 2014, 2(26):4080
[60] Peng J, Zhao Q, Zheng W, et al. ACS Appl Mater Interfaces, 2017, 9(22):18423
[61] Bole A L, Manesiotis P. Adv Mater, 2016, 28(27):5349
[62] Liu L, Yang K, Zhang L, et al. Sci Bull, 2016, 61(24):1890
[63] Lv S W, Liu Y, Xie M, et al. ACS Nano, 2016, 10(6):6201
[64] Liu L K, Yang K G, Dai Z P, et al. Chin Chem Lett, 2019, 30(3):672

循环肿瘤细胞捕获方法的研究进展

Advances in capture methods of circulating tumor cells

PDF

可视化

摘要/Abstract

引用本文

使用本文

扫码分享

参考文献

相关文章 15

编辑推荐

Metrics

[1]	周然锋, 张惠贤, 尹小丽, 彭西甜. 新型纳米材料在农产品安全分析中的应用进展[J]. 色谱, 2023, 41(9): 731-741.
[2]	解伟亚, 朱晓晗, 梅宏成, 郭洪玲, 李亚军, 黄阳, 秦皓, 朱军, 胡灿. 基于功能材料的固相微萃取技术及其在法庭科学领域中的应用[J]. 色谱, 2023, 41(4): 302-311.
[3]	欧阳艺兰, 易琳, 邱露允, 张真庆. 色谱技术在肝素结构分析中的研究进展[J]. 色谱, 2023, 41(2): 107-121.
[4]	翟洪稳, 马红玉, 曹梅荣, 张明星, 马俊美, 张岩, 李强. 在线样品制备技术耦合液相色谱-质谱系统在食品危害物检测中的应用进展[J]. 色谱, 2023, 41(12): 1062-1072.
[5]	余涛, 陈立, 张文敏, 张兰, 卢巧梅. 微孔有机网络材料的合成方法及其在样品前处理中的应用进展[J]. 色谱, 2023, 41(12): 1052-1061.
[6]	郭冬梅, 夏一然, Mujeeb ur RAHMAN, 王建忠, 刘家玮, 白泉. 嵌段共聚温敏亲和色谱固定相的制备及其对抗体的分离纯化[J]. 色谱, 2023, 41(12): 1045-1051.
[7]	王国秀, 陈永雷, 吕文娟, 陈宏丽, 陈兴国. 共价有机框架材料在毛细管电色谱中的应用进展[J]. 色谱, 2023, 41(10): 835-842.
[8]	闫美婷, 龙文雯, 陶雪平, 王丹, 夏之宁, 付琦峰. 金属有机骨架材料在色谱固定相构建及应用中的研究进展[J]. 色谱, 2023, 41(10): 879-890.
[9]	宋春颖, 金高娃, 俞东萍, 夏东海, 丰静, 郭志谋, 梁鑫淼. 超临界流体色谱固定相的发展及在天然产物中的应用[J]. 色谱, 2023, 41(10): 866-878.
[10]	蒋文倩, 陈宇媚, 毕文韬. 基于低共熔溶剂的多孔有机框架材料合成及其在固相萃取中的应用[J]. 色谱, 2023, 41(10): 901-910.
[11]	杨涵, 汤雯淇, 曾楚, 孟莎莎, 徐铭. 高效金属有机骨架气相色谱固定相的理性设计[J]. 色谱, 2023, 41(10): 853-865.
[12]	玛依热·阿不力提甫, 钟子豪, 白希. 制备气相色谱在挥发性成分分离中的应用研究进展[J]. 色谱, 2023, 41(1): 37-46.
[13]	邹晓伟, 刘星, 张建明. 薄层色谱与质谱联用的研究进展[J]. 色谱, 2023, 41(1): 24-36.
[14]	翟容容, 高雯, 李梦宁, 杨华. 离子淌度质谱技术在中药化学成分分析中的研究进展[J]. 色谱, 2022, 40(9): 782-787.
[15]	鲁晨辉, 张毅, 苏宇杰, 王文龙, 冯永巍. 食品中芳香族氨基酸的分离分析技术研究进展[J]. 色谱, 2022, 40(8): 686-693.