Chinese Journal of Chromatography

Chinese Journal of Chromatography ›› 2012, Vol. 30 ›› Issue (10): 1017-1020.DOI: 10.3724/SP.J.1123.2012.08015

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Determination of bisphenol A from toys and food contact materials by derivatization and gas chromatography-mass spectrometry

GAO Yonggang1*, ZHANG Yanyan2, GAO Jianguo1, ZHANG Huiling1, ZHENG Lisha1, CHEN Jing1   

  1. 1. Shandong Exit-Entry Inspection ＆ Quarantine Bureau, Qingdao 266003, China; 2. Qingdao Testing Research Institute of Product Quality, Qingdao 266022, China
  • Received:2012-08-14 Revised:2012-08-29 Online:2012-10-28 Published:2012-10-17

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Abstract: A method was developed for the determination of bisphenol A (BPA) in toys and food contact materials. The BPA was extracted with Soxhlet extraction method from the sample and reacted with acetic anhydride. The final product was determined by gas chromatography-mass spectrometry (GC-MS). To achieve the optimum derivatization performance, the derivatization time and dosage of derivatization reagent etc. were investigated. Under the optimized experimental conditions, the final product was stable and the peak shape was good. The linearity of the derivative was good in the range of 0.05 to 50 mg/L with the correlation coefficient (r2) above 0.999. The recoveries ranged from 80% to 93% at the spiked levels of 0.05, 1.00, 10.00 mg/kg with the relative standard deviations (RSDs) less than 3.7%. The limit of detection (S/N=3) was 10 μg/kg. The method is accurate and has high recovery. The method is suitable for the inspection of bisphenol A in toys and food contact materials.

Key words: acetic anhydride, bisphenol A, food contact materials, gas chromatography-mass spectrometry (GC-MS), toys, pre-column derivatization