Chinese Journal of Chromatography ›› 2015, Vol. 33 ›› Issue (6): 571-576.DOI: 10.3724/SP.J.1123.2015.03019

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Simultaneous determination of ten benzotriazole ultraviolet stabilizers in food contact plastic materials by solid phase extraction and ultra performance liquid chromatography with tandem mass spectrometry

GOU Xinlei1, ZHAO Xinying1, CHI Haitao1, GAO Xia1,2, ZHOU Mingqiang1, LIU Weili1,2   

  1. 1. Beijing Key Laboratory of Detection Technology and Quality Evaluation of Organic Material, Beijing Center for Physical and Chemical Analysis, Beijing 100089, China;
    2. Beijing Engineering Research Center of Food Safety Analysis, Beijing 10089, China
  • Received:2015-03-16 Online:2015-06-08 Published:2015-05-26

Abstract:

A sensitive method was developed for the simultaneous determination of ten benzotriazole ultraviolet stabilizers in food contact plastic materials by ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The sample was extracted by methanol-dichloromethane, and purified by a C18 solid-phase extraction (SPE) column. The separation was performed by using water containing 0.1% (v/v) formic acid and methanol as the mobile phases with gradient elution at a flow rate of 0.3 mL/min. The electrospray ionization (ESI) source in positive ion mode was used for the analysis of the ten benzotriazole ultraviolet stabilizers in multiple reaction monitoring (MRM) mode. The results showed that the standard curves were obtained with good correlation coefficients (r2>0.996) in their linear concentration ranges. The limits of detection (LODs, S/N=3) for the ten benzotriazole ultraviolet stabilizers were in the range of 0.6-1.6 μg/kg. The mean recoveries for the ten benzotriazole ultraviolet stabilizers at three spiked levels (low, medium and high) were 75.2%-85.3% with relative standard deviations of 1.0%-5.7%. Ten kinds of food contact plastic materials were tested, and 2,2'-methylenebis(6-(benzotriazol-2-yl)-4-tert-octylphenol) (UV-360) was found in a sample of polyethylene (PE) material. The method is accurate, simple, rapid and feasible for the simultaneous determination of benzotriazole ultraviolet stabilizers in food plastic materials.

Key words: benzotriazoles (BZTs), food contact plastic materials, ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), ultraviolet stabilizers

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