Simultaneous determination of 22 typical pharmaceuticals and personal care products in environmental water using ultra performance liquid chromatography- triple quadrupole mass spectrometry
WU Chunying1,2, GU Feng1, BAI Lu1, LU Wenlong1
1. School of Resources and Environmental Engineering, Jilin Institute of Chemical Technology, Jilin 132022, China;
2. School of Environment, Tsinghua University, State Key Laboratory of Environmental Simulation and Pollution Control, Beijing 100084, China
An analytical method for simultaneous determination of 22 typical pharmaceuticals and personal care products (PPCPs) in environmental water samples was developed by ultra performance liquid chromatography-triple quadrupole mass spectrometry (UPLC-MS/MS). An Oasis HLB solid phase extraction cartridge, methanol as washing solution, water containing 0.1% formic acid-methanol (7:3, v/v) as the mobile phases were selected for sample pretreatment and chromatographic separation. Based on the optimized sample pretreatment procedures and separation condition, the target recoveries ranged from 73% to 125% in water with the relative standard deviations (RSDs) from 8.8% to 17.5%, and the linear ranges were from 2 to 2000 μg/L with correlation coefficients (R2) not less than 0.997. The method can be applied to simultaneous determination of the 22 typical PPCPs in environmental water samples because of its low detection limits and high recoveries. It can provide support and help for the related research on water environmental risk assessment and control of the micro-organic pollutants.
WU Chunying,GU Feng,BAI Lu et al. Simultaneous determination of 22 typical pharmaceuticals and personal care products in environmental water using ultra performance liquid chromatography- triple quadrupole mass spectrometry[J]. Chinese Journal of Chromatography, 2015, 33(8): 843-848.