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Chinese Journal of Chromatography
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Chinese Journal of Chromatography  2015, Vol. 33 Issue (8): 856-863    DOI: 10.3724/SP.J.1123.2015.04011
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Simultaneous determination of total specific migration limit of seven benzene polycarbonic acids and their derivatives in food simulants by high performance liquid chromatography-ultraviolet detection
WANG Jianling, XIAO Xiaofeng, CHEN Tong, LIU Tingfei, HE Jun, DENG Hongyi, YANG Juanjuan
Taizhou Entry-Exit Inspection and Quarantine Bureau, Taizhou 318000, China
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Abstract 

A novel method for simultaneous determination of total specific migration limits (SML(T)) of trimellitic, isophthalic, terephthalic, phthalic acid and their derivatives (1,2,4-benzenetricarboxylic anhydride, isophthaloyl chloride and terephthaloyl chloride) in food simulants (10% (v/v) ethanol, 20% (v/v) ethanol, 50% (v/v) ethanol, 3% (w/v) acetic acid and olive oil) was developed by high performance liquid chromatography-ultraviolet detection (HPLC-UV). After the migration test, the soaking solution was cooled down and vortexed. After the extraction of olive oil food simulants with 0.1% (w/v) ammonium acetate aqueous solution, the clear aqueous solution or other aqueous food simulants was filtered through a hydrophilic polytetrafluoroethylene filter with a disposable syringe before injection. The Synergi Polar-RP column (250 mm×4.6 mm, 4 μm) and gradient elution mode were selected. The variable wavelength detector was set at 232 nm. The limits of quantification were 0.1-0.2 mg/kg; the linearity of the method was good with r2>0.99991 over the range from 0.5 to 12 mg/L for aqueous food simulants or 0.5 to 12 mg/kg for olive oil food simulants. The recoveries of them were between 94.3% and 105% with the relative standard deviations between 0.1% and 2.3% at the levels of 1.25, 2.50, 6.25 mg/kg. The method shows the low limits of detection, good recoveries and accuracies, and meets the requirement of (EU)No 10/2011 regulation for the total specific migration limits of trimellitic, isophthalic, terephthalic, phthalic acids and their derivatives. The method has been applied to the analysis of food contact material samples.

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Articles by authors
WANG Jianling
XIAO Xiaofeng
CHEN Tong
LIU Tingfei
HE Jun
DENG Hongyi
YANG Juanjuan
Key wordshigh performance liquid chromatography-ultraviolet detection (HPLC-UV)   trimellitic acid   isophthalic acid   terephthalic acid   phthalic acid   total specific migration limit (SML(T))     
Received: 2015-04-08;
Cite this article:   
WANG Jianling,XIAO Xiaofeng,CHEN Tong et al. Simultaneous determination of total specific migration limit of seven benzene polycarbonic acids and their derivatives in food simulants by high performance liquid chromatography-ultraviolet detection[J]. Chinese Journal of Chromatography, 2015, 33(8): 856-863.
 
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