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Chinese Journal of Chromatography
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Chinese Journal of Chromatography  2015, Vol. 33 Issue (8): 897-901    DOI: 10.3724/SP.J.1123.2015.03020
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Rapid screening and confirmation of illegally added anti-impotence preparations in health care products by high performance liquid chromatography-high resolution mass spectrometry
HU Tingting1,2, QU Xiaoyu3, KANG Mingqin1, SONG Qinglian1, YANG Lu1, ZHAO Yunhui1, ZHANG Daihui1
1. Jilin Entry-Exit Inspection and Quarantine Bureau, Changchun 130062, China;
2. Public Health College of Jilin University, Changchun 130021, China;
3. The First Hospital of Jilin University, Changchun 130021, China
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Abstract 

A method was established for rapid screening and quantifying 11 illegally added anti-impotence preparations (yohimbine, acetildenafil, nor-acetildenafil, homosildenafil, hydroxyhomosildenafil, sildenafil, vardenafil, thioaildenafil, tadalafil, pseudovardenafil, dapoxetine) in health care products by high performance liquid chromatography-high resolution mass spectrometry. The samples were extracted with methanol and analyzed by positive mode in the MS detection. The results showed that the limits of detection were 25.0 ng/mL except for nor-acetildenafil (5.0 ng/mL), the linear ranges were 5.0-200.0 ng/mL except for nor-acetildenafil (25.0-500.0 ng/mL) with the correlation coefficients not less than 0.9990. The recoveries were in the range of 82.0%-105.9% with the relative standard deviations of 4.7%-16.5%. This method is accurate, simple and rapid, and can be used in rapid screening and quantitative analysis of the 11 illegally added anti-impotence in health care products.

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Articles by authors
HU Tingting
QU Xiaoyu
KANG Mingqin
SONG Qinglian
YANG Lu
ZHAO Yunhui
ZHANG Daihui
Key wordshigh performance liquid chromatography-high resolution mass spectrometry (HPLC-HRMS)   anti-impotence preparations   health care products   rapid screening     
Received: 2015-03-16;
Cite this article:   
HU Tingting,QU Xiaoyu,KANG Mingqin et al. Rapid screening and confirmation of illegally added anti-impotence preparations in health care products by high performance liquid chromatography-high resolution mass spectrometry[J]. Chinese Journal of Chromatography, 2015, 33(8): 897-901.
 
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