Simultaneous determination of perfluoric acid, perfluorooctane sulfonic acid, bisphenol A, nonylphenol in infant milk powder by high-performance liquid chromatography-tandem mass spectrometry

doi:10.3724/SP.J.1123.2018.07011

Abstract

Abstract:

A rapid confirmative method was developed for determining the residues of perfluoric acid (PFOA), perfluorooctane sulfonic acid (PFOS), bisphenol A (BPA), and nonylphenol (NP) in infant milk powder by HPLC-MS/MS. The sample was dissolved in water by ultrasonication, and the protein was removed by dissolving in acetonitrile. The analytes were separated on a Hypersil GOLD C₁₈ column (150 mm×2.0 mm, 5 μm) using 30 mmol/L ammonium acetate solution and methanol as mobile phases, with gradient elution at a flow rate of 0.3 mL/min. Finally, the samples were determined by HPLC-MS/MS. Internal matrix-matched calibration was used for quantification. The limits of quantification (LOQs, S/N=10) of PFOA, PFOS, BPA, and NP were 0.5, 1.0, 10.0, and 5.0 μg/kg, respectively. The recoveries ranged from 86.1% to 106.8%, and the relative standard deviations (RSDs) were in the range from 2.87% to 9.53%. The method was also applied to real samples. The results showed that the method was simple and accurate, and can be used for determining the residues of PFOA, PFOS, BPA, and NP in infant milk powder.

Key words: bisphenol A (BPA), high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS), infant milk powder, nonylphenol (NP), perfluoric acid (PFOA), perfluorooctane sulfonic acid (PFOS)

CLC Number:

O658

WANG Hao, SHAO Mingyuan, JIA Jingyi, LIU Mingyan, PEI Fan. Simultaneous determination of perfluoric acid, perfluorooctane sulfonic acid, bisphenol A, nonylphenol in infant milk powder by high-performance liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Chromatography, 2018, 36(12): 1279-1283.

References

[1] Dai Z Y, Zhang Y C, Liu Y H. China Dairy, 2001, 112(4):58 戴智勇, 张岩春, 刘跃辉. 中国乳业, 2001, 112(4):58
[2] Betts K S. Environ Sci Technol, 2003, 37(17):312
[3] Luo J J. Modern Agricultural Science and Technology, 2015(1):288 罗纪军. 现代农业科技, 2015(1):288
[4] Qu S S.[MS Dissertation]. Harbin::East University of Heilongjiang, 2016 曲双双.[硕士学位论文]. 哈尔滨:黑龙江东方学院, 2016
[5] Niu Y M, Zhang J, Zhang S J, et al. Chinese Journal of Analytical Chemistry, 2012, 40(4):534 牛宇敏, 张晶, 张书军, 等. 分析化学, 2012, 40(4):534
[6] Song X, Hang X Y, Wang Q, et al. Physical Testing and Chemical analysis, Part B:Chemcial Analysis, 2018, 54(5):611 宋鑫, 杭学宇, 王芹, 等. 理化检验-化学分册, 2018, 54(5):611
[7] Zhang M J, An Y, Tang X, et al. Farm Products Processing, 2017(12):49 张敏娟, 安瑜, 唐欣, 等. 农产品加工, 2017(12):49
[8] Qu S S, Xiao G H, Liu T, et al. China Food Additives, 2016(8):185 曲双双, 肖光辉, 刘婷, 等. 中国食品添加剂, 2016(8):185
[9] Cheng Y, Tang J, He Q F, et al. Journal of Anhui Agriculture Science, 2016, 44(32):71 程燕, 汤婕, 何前锋, 等. 安徽农业科学, 2016, 44(32):71
[10] Chen Y, Li K B, Liao M L, et al. Guangdong Chemical Industry, 2016, 43(9):223 陈燕, 李康柏, 廖敏立, 等. 广东化工, 2016, 43(9):223
[11] Li W, Zhao X X, Li F H, et al. Preventive Medicine Tribune, 2017, 23(3):233 李蔚, 赵秀香, 李凤华, 等. 预防医学论坛, 2017, 23(3):233
[12] Zhou J K, Zhang Q L, Han K, et al. Science and Technology of Food Industry, 2007, 28(2):233 周建科, 张前莉, 韩康, 等. 食品工业科技, 2007, 28(2):233
[13] Tian H Z, Xu J. Food Science and Technology, 2012, 37(8):286 田宏哲, 徐静. 食品科技, 2012, 37(8):286
[14] Wu W J, Li X, Liu J, et al. Science and Technology of Cereals, Oils and Foods, 2016, 24(6):67 吴维吉, 李旭, 刘吉, 等. 粮油食品科技, 2016, 24(6):67
[15] Huang H, Deng X X, Zhang H W, et al. Food Science, 2013, 34(24):116 黄会, 邓旭修, 张华威, 等. 食品科学, 2013, 34(24):116