Abstract: This review summarizes recent developments and applications of microchip electrochromatography (μCEC) mainly in the past five years between 2005 and 2009 with a focus on column technologies. In addition, some new improvements in the chip design and fabrication, sample preconcentration, electroosmotic flow control as well as mechanisms that govern electrochromatographic separation are described and reviewed. The features and limitations of several practical aspects of their applications are highlighted.

Key words: capillary electrochromatography (CEC), electroosmotic flow (EOF), monolithic column, review , micro-chip