基于混合模式的高效液相色谱固定相研究进展

李世杰, 李振, 汤紫霞, 吕美, 王利涛

Research progress on high performance liquid chromatography stationary phases based on mixed mode

LI Shijie, LI Zhen, TANG Zixia, LYU Mei, WANG Litao

表1 RPLC/IEC混合模式固定相的信息及分离物质

Table 1 RPLC/IEC mixed-mode stationary phase information and separated substances

Stationary phase Functional ligand Hydrophobic interactions Ion-exchange interactions Samples Ref. Silica-PILs 1-（4-vinylbenzyl） -3-cyanomethyl imidazolium bromide benzene ring imidazole cationic substituent polycyclic aromatic hydrocarbons， alkylbenzene， nonsteroidal anti-inflammatory drugs ［22］ C18/TMA ODS， 3-glycidoxypropyltrimethoxysilane， TMA ODS quaternary ammonium group non-polar substance， small molecule base， aromatic acid ［45］ Sil-PBQA amino anion exchange groups， benzene rings， and quaternary ammonium salts containing benzyl groups benzene ring quaternary ammonium group nonsteroidal anti-inflammatory drugs ［46］ Sil-VDI VDI， thiol functionalized SiO2 alkyl imidazole cationic substituent hydrophobic alkylbenzene， polycyclic aromatic hydrocarbons and benzene derivatives， inorganic anions ［47］ SiO2-UI-PMA UI， PMA alkyl， PMA imidazole cationic substituent EED， sulfonamide drugs， foodborne stimulants， and inorganic anions ［48］ Cys-silica-Cn， n=2， 8 and 18 cysteine and vinyl functionalized SiO2， bromoethane， 1-bromooctane， and 1-bromooctadecane alkyl quaternary ammonium group， cysteine 6 alkaline proteins， 5 acidic proteins ［49］ Sil-peptoids vinyl modified SiO2， three small peptides hydrophobic carbon chain -COOH， -NH2 acidic， polar and non-polar molecules， nonsteroidal anti-inflammatory drugs ［50］