色谱

色谱 ›› 2016, Vol. 34 ›› Issue (6): 596-601.DOI: 10.3724/SP.J.1123.2016.03019

• 研究论文 • 上一篇    下一篇

萃取纳升喷雾-离子迁移谱法现场快速筛查化妆品中8种禁用抗生素

孟宪双1, 马强1, 马龙华2, 陈丽华3, 韩超4, 白桦1, 吴青2   

  1. 1. 中国检验检疫科学研究院, 北京 100176;
    2. Excellims Corporation, Acton, MA 01720, USA;
    3. 重庆出入境检验检疫局, 重庆 400020;
    4. 温州出入境检验检疫局, 浙江 温州 325027
  • 收稿日期:2016-03-15 出版日期:2016-06-08 发布日期:2013-01-23
  • 通讯作者: 马强
  • 基金资助:

    国家质检总局科技计划项目(2015IK314);中央级公益性科研院所基本科研业务费专项资金资助项目(2016JK004)

Rapid on-site screening of eight prohibited antibiotics in cosmetics using extraction nano-electrospray coupled with ion mobility spectrometry

MENG Xianshuang1, MA Qiang1, MA Longhua2, CHEN Lihua3, HAN Chao4, BAI Hua1, WU Qing2   

  1. 1. Chinese Academy of Inspection and Quarantine, Beijing 100176, China;
    2. Excellims Corporation, Acton, MA 01720, USA;
    3. Chongqing Entry-Exit Inspection and Quarantine Bureau, Chongqing 400020, China;
    4. Wenzhou Entry-Exit Inspection and Quarantine Bureau, Wenzhou 325027, China
  • Received:2016-03-15 Online:2016-06-08 Published:2013-01-23
  • Supported by:

    Science Research Program of General Administration of Quality Supervision, Inspection and Quarantine of China (No. 2015IK314);Basic Research Fund for Central Public Interest Institutes (No. 2016JK004).

PDF

100

被引次数

5

摘要：

采用萃取纳升喷雾结合离子迁移谱技术,建立了化妆品中8种禁用抗生素的现场快速筛查方法。对萃取纳升喷雾毛细管拉制条件、萃取纳升喷雾离子化条件、离子迁移谱检测条件等进行了详细考察和优化。在优化的实验条件下,8种禁用抗生素的方法检出限为20 mg/kg,离子迁移谱分析时间小于20 ms,单个样品全部检测时间不超过30 s。对于筛检出的疑似阳性样品,进一步采用超高效液相色谱-串联质谱进行确证。该方法流程简便、快捷高效,为化妆品中违禁组分的现场快速筛查提供了较为广阔的应用前景。

关键词: 萃取纳升喷雾, 化妆品, 禁用抗生素, 离子迁移谱, 现场快速筛查

Abstract:

A rapid on-site method has been developed for the identification of eight prohibited antibiotics in cosmetics using extraction nano-electrospray coupled with ion mobility spectrometry. The experimental conditions for capillary pulling, extraction nano-electrospray, and ion mobility spectrometry were investigated and optimized. Under the optimum conditions, the limits of detection (LODs) for the eight prohibited antibiotics were 20 mg/kg. The instrumental analysis time for a single ion mobility spectrometry run was less than 20 ms, and the total period for sample analysis was less than 30 s. The suspicious positive samples were subjected to further verification by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The proposed method is rapid, efficient with greatly simplified work flows and can provide potential analytical possibility for outside-the-lab screening of cosmetics for the presence of illicit ingredients.

Key words: cosmetics, extraction nano-electrospray, ion mobility spectrometry (IMS), prohibited antibiotics, rapid on-site screening

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