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生物样品中儿茶酚胺类物质分析方法的研究进展

顾群,石先哲,许国旺   

  1. National Chromatographic R. &A. Center, Dalian Institute of Chemical Physics, the Chinese
    Academy of Sciences, Dalian 116023, China
  • 收稿日期:2006-12-31 修回日期:2007-03-07 出版日期:2007-07-30 发布日期:1985-06-25
  • 通讯作者: 顾群

Advances in Catecholamine Analysis in Biological Samples

GU Qun, SHI Xianzhe, XU Guowang   

  1. National Chromatographic R. &A. Center, Dalian Institute of Chemical Physics, the Chinese
    Academy of Sciences, Dalian 116023, China
  • Received:2006-12-31 Revised:2007-03-07 Online:2007-07-30 Published:1985-06-25

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摘要： 儿茶酚胺是人体内重要的神经递质,血浆及尿中儿茶酚胺的浓度水平可用于诊断高血压、嗜铬细胞瘤及成神经细胞瘤等病症,因而准确测定人体生物样品中儿茶酚胺类物质代谢浓度的变化，在疾病的诊断和治疗中具有重要的意义。该文综述了人体液和组织中儿茶酚胺类物质的不同分析方法,包括高效液相色谱法、毛细管电泳法、质谱法、电化学法、化学发光法、荧光光度法等。

关键词: 电化学法, 儿茶酚胺类物质, 高效液相色谱法, 化学发光法, 毛细管电泳法, 生物样品, 荧光光度法 , 质谱法

Abstract: Catecholamines are important neurotransmitters in human organism. Catecholamine levels in plasma and urine are utilized to diagnose hypertension, pheochromocytoma and neuroblastoma. This review reports different analytical methods for catecholamines, such as high performance liquid chromatography, capillary electrophoresis, mass spectrometric detection, electrochemical detection, chemiluminescence detection and fluorescence detection.

Key words: capillary electrophoresis, catecholamines, chemiluminescence detection, fluorescence detection , high performance liquid chromatography, mass spectrometric detection； electrochemical detection, biological samples