色谱

色谱

• 样品预处理方法专栏 • 上一篇    下一篇

体液的在线样品前处理技术及其小分子化合物的液相色谱-质谱分析

刘敏,赵利霞,郭宝元,林金明

  

  1. State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, the Chinese Academy of Sciences, Beijing 100085, China

  • 收稿日期:2007-08-24 修回日期:1900-01-01 出版日期:2007-09-30 发布日期:1985-03-25
  • 通讯作者: 林金明

Development of On-Line Sample Preparation Coupled with Liquid Chromatography-Mass Spectrometry for
Analysis of Small Molecules in Biofluids

LIU Min, ZHAO Lixia, GUO Baoyuan, LIN Jin-Ming

  

  1. State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, the Chinese Academy of Sciences, Beijing 100085, China

  • Received:2007-08-24 Revised:1900-01-01 Online:2007-09-30 Published:1985-03-25
  • Contact: LIN Jin-Ming

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摘要：

在线样品前处理液相色谱-质谱联用技术为体液中痕量小分子化合物提供了高灵敏度、高选择性和高通量的分析方法。该文以在线固相萃取柱为主线,总结了不同种类富集柱的特点及其近5年来在相关领域的应用，并简要介绍了在线液相色谱-质谱分析的流路系统。

关键词: 在线固相萃取, 体液, 小分子化合物, 液相色谱-质谱, 综述

Abstract:

On-line liquid chromatography-mass spectrometry (LC-MS) is a highly sensitive, highly selective and high throughput method for the analysis of small molecules in biofluids. The developments, characterizations and applications of pre-column, on-line LC-MS method and its configuration in the recent five years are reviewed.

Key words: biofluids, liquid chromatography-mass spectrometry (LC-MS), review , small molecules, on-line solid phase extraction