色谱

色谱

• 兴奋剂检测方法专栏 • 上一篇    下一篇

兴奋剂重组人促红细胞生成素及其类似物检测方法的研究进展

杨霞,庞楠楠,廖一平,刘虎威   

  1. Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
  • 收稿日期:2008-07-30 修回日期:2008-07-30 出版日期:2008-07-30 发布日期:1983-12-25
  • 通讯作者: 刘虎威
  • 基金资助:
    国家自然科学基金资助项目(No. 20635001).

Recent advances in the detection of recombinant human erythropoiesis and its analogs in doping control

YANG Xia, PANG Nannan, LIAO Yiping, LIU Huwei   

  1. Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
  • Received:2008-07-30 Revised:2008-07-30 Online:2008-07-30 Published:1983-12-25
  • Contact: LIU Huwei

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被引次数

1

摘要： 重组人促红细胞生成素(rhEPO)是一种激素类兴奋剂,近年来被滥用在一些耐力性比赛项目中。由于重组与内源性EPO的氨基酸序列相同,区别很小,并且在尿样或血样中的浓度低,代谢快,给检测带来了很大的难度。本文从直接方法和间接方法两个方面综述了近几年来兴奋剂rhEPO及其类似物检测的研究进展,并结合本小组的工作展望了rhEPO检测的发展方向。

关键词: 间接方法, 检测, 兴奋剂, 直接方法, 重组人促红细胞生成素, 综述

Abstract: Recombinant human erythropoietin (rhEPO) is one of hormone dopings. In the recent years, it has been always misused in endurance competition sports. It is extremely difficult to discriminate between the natural endogenous erythropoietin (EPO) and recombinant exogenous hormone because they have identical amino acid sequences, and EPO has a relatively short half-life and very low concentration in blood or urine. In this paper, the research progress on the analysis and detection of rhEPO and its analogs by direct and indirect methods are reviewed. Future direction and prospects of the detection of rhEPO in doping control are discussed based on the research of our group.

Key words: detection, direct methods, doping, indirect methods, review , recombinant human erythropoietin （rhEPO）