色谱

色谱 ›› 2016, Vol. 34 ›› Issue (1): 57-61.DOI: 10.3724/SP.J.1123.2015.10002

• 研究论文 • 上一篇    下一篇

高效液相色谱法手性分离二茂铁衍生物

徐峰1, 万晓龙1, 王军锋2, 康经武1   

  1. 1. 中国科学院上海有机化学研究所, 生命有机和天然产物化学国家重点实验室, 上海 200032;
    2. 陕西学前师范学院化学与化工系, 陕西 西安 710100
  • 收稿日期:2015-10-07 出版日期:2016-01-08 发布日期:2012-08-01
  • 通讯作者: 康经武

Enantioseparation of ferroence derivatives with high performance liquid chromatography

XU Feng1, WAN Xiaolong1, WANG Junfeng2, KANG Jingwu1   

  1. 1. State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China;
    2. Department of Chemistry and Chemical Engineering, Shaanxi Xueqian Normal University, Xi'an 710100, China
  • Received:2015-10-07 Online:2016-01-08 Published:2012-08-01

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被引次数

1

摘要：

建立了4个单手性和3个双手性(含有手性中心和面手性)的二茂铁衍生物在Chiralpak IC(纤维素-三(3,5-二氯苯基氨基甲酸酯))和Chiralpak IE3(直链淀粉-三(3,5-二氯苯基氨基甲酸酯))手性固定相上的高效液相色谱分离方法。4个单手性二茂铁衍生物中有3个可以在Chiralpak IE3固定相上实现基线分离,另外1个则在Chiralpak IC手性固定相上实现基线分离。3个双手性二茂铁衍生物可在Chiralpak IC手性固定相上实现基线分离。研究表明,这两种手性固定相对二茂铁衍生物具有较好的手性识别作用,并且具有互补作用。这一研究结果可为手性二茂铁化合物的分离提供借鉴和参考。

关键词: 二茂铁衍生物, 高效液相色谱, 手性分离, 手性固定相, 纤维素-三(3,5-二氯苯基氨基甲酸酯), 直链淀粉-三(3,5-二氯苯基氨基甲酸酯)

Abstract:

The method for the enantioseparation of ferroence derivatives, four derivatives with single chirality and three derivatives with double chiralities containing centre and face chirality, on chiral stationary phases, namely Chiralpak IC (cellulose-tris(3,5-dichlorobenzene carbamate)) and Chiralpak IE3 (amylose-tris(3,5-dichlorobenzene carbamate)), was investigated. We found that the three derivatives of the four chiral ferroence derivatives with single chirality can be baseline separated on Chiralpak IE3; another one can be baseline separated on Chiralpak IC. Meanwhile, the three chiral ferroence derivatives with double chiralities can be baseline separated on Chiralpak IC. The research shows that the both kinds of chiral stationary phases exhibited high enantiomeric recognition capability to the enantiomers of the chiral ferroence derivatives. This two chiral stationary phases exhibited complementary selectivities in the enantioseparation of chiral ferroence derivatives. This study provides a reference method for the enantioseparation of chiral ferroence derivatives.

Key words: amylose-tris(3,5-dichlorobenzene carbamate), cellulose-tris(3,5-dichlorobenzene carbamate), chiral stationary phase, enantioseparation, ferroence derivatives, high performance liquid chromatography (HPLC)

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