色谱

色谱 ›› 2024, Vol. 42 ›› Issue (2): 211-216.DOI: 10.3724/SP.J.1123.2023.09023

• 研究论文 • 上一篇    下一篇

母乳中全氟及多氟烷基化合物污染水平及婴儿暴露风险评估

陈海川, 曹文成, 刘小方, 刘潇, 程青云, 周妍(), 闻胜()   

  1. 湖北省疾病预防控制中心应用毒理湖北省重点实验室, 湖北 武汉 430079
  • 收稿日期:2023-09-25 出版日期:2024-02-08 发布日期:2024-02-20
  • 通讯作者: * E-mail:wenshenggy@aliyun.com(闻胜); E-mail:zy_hbcdc@163.com(周妍).
  • 基金资助:
    国家重点研发计划项目(2017YFC1600500);湖北省自然科学基金计划项目(2022CFB022);湖北省自然科学基金计划项目(2023AFB1012);湖北省医学青年拔尖人才项目(S2020JY23);湖北省卫生健康科研基金项目(WJ2023M106);湖北省卫生健康科研基金项目(WJ2021Q049)

Contamination levels of perfluorinated and polyfluoroalkyl compounds in breast milk and assessment of their exposure risk to infants

CHEN Haichuan, CAO Wencheng, LIU Xiaofang, LIU Xiao, CHENG Qingyun, ZHOU Yan(), WEN Sheng()   

  1. Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Center for Disease Control and Prevention, Wuhan 430079, China
  • Received:2023-09-25 Online:2024-02-08 Published:2024-02-20
  • Supported by:
    National Key R & D Project(2017YFC1600500);Project of Natural Science Foundation of Hubei Province(2022CFB022);Project of Natural Science Foundation of Hubei Province(2023AFB1012);Medical Young Top Talent Project in Hubei Province(S2020JY23);Project of Health Research Fund of Hubei Province(WJ2023M106);Project of Health Research Fund of Hubei Province(WJ2021Q049)

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摘要：

为探究母乳中全氟及多氟烷基化合物(PFASs)的污染水平及婴儿暴露风险,本研究依托2018-2021年湖北应城的出生队列,采用同位素稀释-高效液相色谱-串联质谱法测定了324名产妇母乳中23种PFASs的含量,使用多元线性回归分析人口学特征、饮食习惯对产妇母乳PFASs含量的影响,估算婴儿经母乳的PFASs每日摄入量并评估其暴露风险。结果表明,母乳中23种PFASs在0.2~100 ng/mL范围内线性关系良好,相关系数均大于0.992,检出限为5~42 pg/mL,定量限为15~126 pg/mL,回收率为65.6%~108.1%,相对标准偏差为1.6%~12.8%。全氟辛烷磺酸(PFOS)、全氟辛酸(PFOA)和全氟己烷磺酸(PFHxS)为主要污染物,检出率均高于80%,中位数分别为200.7、63.5和25.2 pg/mL,其余化合物检出率均低于45%。多元线性回归结果表明,产妇年龄大、腌制食品摄入频率高可能与母乳PFASs暴露水平增高有关,豆类食品摄入频率高可能与母乳PFASs暴露水平降低有关。婴儿经母乳PFOS、PFOA和PFHxS的每日估计摄入量中位数分别为25.1、7.9和3.2 ng/(kg·d),表明部分婴儿经母乳摄入的PFASs健康风险值得关注。

关键词: 全氟及多氟烷基化合物, 母乳, 污染水平, 影响因素, 婴儿暴露风险

Abstract:

The purposes of this study are to explore the contamination levels of perfluorinated and polyfluoroalkyl substances (PFASs) in breast milk and assess their exposure risk to infants. Based on data from a birth cohort study conducted in Yingcheng, Hubei Province, from 2018 to 2021, the contents of 23 types of PFASs in the breast milk of 324 pregnant women were determined using isotope dilution-high performance liquid chromatography-tandem mass spectrometry. Multiple linear regression was then performed to analyze the effects of various demographic characteristics and eating habits on the concentration of PFASs in breast milk. The daily PFASs intake of infants through breast milk was estimated, and the exposure risk of infants was also assessed. The results revealed that 23 types of PFASs in breast milk had good linear relationships in the range of 0.2-100 ng/mL, with correlation coefficients greater than 0.992. The limits of detection were 5-42 pg/mL, the limits of quantification were 15-126 pg/mL, the recoveries were 65.6%-108.1%, and the relative standard deviations were 1.6%-12.8%. Perfluorooctane sulfonic acid (PFOS), perfluorooctanoate acid (PFOA), and perfluorohexanesulfonic acid (PFHxS), with median concentrations of 200.7, 63.5, and 25.2 pg/mL, respectively, were the main PFASs found in breast milk. The detection rates of these three contaminants were higher than 80%, whereas the detection rates of other compounds were lower than 45%. The results of multiple linear regression showed that older pregnant women and a higher frequency of pickled food intake may be related to increased PFAS levels in breast milk whereas a higher frequency of legume intake may be related to decreased PFAS levels in breast milk. The median estimated daily intakes (EDIs) of PFOS, PFOA, and PFHxS for infants were 25.1, 7.9, and 3.2 ng/(kg·d), respectively. In summary, this study found notable PFAS levels in breast milk in Yingcheng, Hubei Province. Among these PFASs, PFOS, PFOA, and PFHxS were the main contaminants. Maternal age as well as pickled food and legume intake may affect the PFAS level in breast milk. The health risk of PFAS intake through breast milk to some infants is worthy of attention and further study.

Key words: perfluorinated and polyfluoroalkyl substances (PFASs), breast milk, pollution level, influencing factors, infant exposure risk

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