色谱

色谱 ›› 2024, Vol. 42 ›› Issue (10): 1006-1012.DOI: 10.3724/SP.J.1123.2024.03003

• 教学研究 • 上一篇    

本科生综合实验:基于共价有机框架的核壳型固定相的制备及色谱性能评价

刘锦, 田文锠, 吴帆, 张秋婷, 钟燕辉, 林子俺()   

  1. 福州大学化学学院, 食品安全与生物分析教育部重点实验室, 福建省食品安全分析与检测重点实验室, 福建 福州 350108
  • 收稿日期:2024-03-04 出版日期:2024-10-08 发布日期:2024-09-27
  • 通讯作者: * E-mail:zianlin@fzu.edu.cn.
  • 基金资助:
    国家自然科学基金(22274021);福建省自然科学基金(2022J01535);福建省本科高校教育教学研究项目(FBJG20220268);福州大学本科教育教学研究项目

A comprehensive undergraduate experiment: preparation and chromatographic evaluation of a core-shell stationary phase based on a covalent organic framework

LIU Jin, TIAN Wenchang, WU Fan, ZHANG Qiuting, ZHONG Yanhui, LIN Zian()   

  1. Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou 350108, China
  • Received:2024-03-04 Online:2024-10-08 Published:2024-09-27
  • Supported by:
    National Natural Science Foundation of China(22274021);Natural Science Foundation of Fujian Province(2022J01535);Undergraduate Education and Teaching Research Project of Fujian Province(FBJG20220268);Fuzhou University Undergraduate Education Teaching Research Project

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摘要：

在教育部不断推进新课程标准的背景下,本文介绍了一项面向本科生仪器分析课程的综合性教学实验,旨在通过实践提高学生在材料制备和仪器使用方面的技能。该实验通过“一锅法”制备了一种基于共价有机框架的核壳结构固定相材料(SiO2@COFTTA-DHTA),并对其进行了详细的理化表征。随后,采用高效液相色谱技术对该材料的色谱性能进行了评估。整个实验流程包括了材料合成、表征、色谱保留行为研究和色谱分离性能测试。该实验不仅加深了学生对于功能材料性质及其应用的理解,而且提高了他们的实验设计和批判性思维能力。通过理论科学与实验教学的结合,该实验不仅能够培养学生的科研兴趣,还可以锻炼实验操作能力、创新思维和实践能力,同时增强学生的社会责任感和历史使命感,实现实验教学的全方位育人目标。

关键词: 综合性实验, 共价有机框架, 色谱固定相, 核壳结构

Abstract:

Continuously promoting new curriculum standards is a key aim of the Ministry of Education of China. With this in mind, this paper introduces a comprehensive teaching experiment for undergraduate instrumental analysis courses that aims to improve students’ material-preparation and instrumental-analysis skills through practice. Herein, a covalent organic framework-based core-shell stationary phase material (SiO2@COFTTA-DHTA) is prepared via a one-pot method and characterized in detail, after which its chromatographic properties are evaluated by high performance liquid chromatography (HPLC). The experimental process includes material synthesis and characterization, as well as studying the chromatographic-retention behavior and chromatographic-separation performance of the material. By the combining theoretical science and experimental teaching, this experiment not only deepens students’ understanding of the properties of functional materials and their applications, but also improves their experimental-design and critical-thinking skills. This experiment not only cultivates students’ interests in scientific research, but also exercises their experimental, operational, innovative-thinking, and practical abilities, while concurrently enhancing their sense of social responsibility and historical mission, thereby delivering the all-round educational goals of experimental teaching.

Key words: comprehensive experiment, covalent organic framework, chromatographic stationary phase, core-shell structure

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