色谱

色谱 ›› 2011, Vol. 29 ›› Issue (04): 284-292.DOI: 10.3724/SP.J.1123.2011.00284

• 特别策划 • 上一篇    下一篇

近期微流控芯片疾病诊断技术的研究进展

李海芳1, 张倩云1,2, 林金明1*   

  1. 1. 清华大学化学系, 北京 100084; 2. 北京化工大学理学院, 北京 100029
  • 收稿日期:2011-02-25 修回日期:2011-03-03 出版日期:2011-04-28 发布日期:2011-04-28
  • 通讯作者: 林金明,博士,教授,研究方向为微流控芯片新技术、化学发光、免疫分析等
  • 基金资助:

    国家自然科学基金项目(30772006).

Recent development of microfluidic diagnostic technologies

LI Haifang1, ZHANG Qianyun1,2, LIN Jin-Ming1*   

  1. 1. Department of Chemistry, Tsinghua University, Beijing 100084, China; 2. School of Science, Beijing University of Chemical Technology, Beijing 100029, China
  • Received:2011-02-25 Revised:2011-03-03 Online:2011-04-28 Published:2011-04-28

PDF

1326

被引次数

12

摘要： 微流控芯片具有液流可控、样品消耗量小、反应速度快、易于集成化等特点,在临床诊断和疾病筛查领域具有广阔的发展前景。本文针对近年来微流控芯片技术在疾病诊断方面的最新研究进展,从疾病标志物检测、细胞筛选和药物代谢研究及疾病诊断微流控芯片装置的发展现状等方面概述其在疾病诊断方面的应用和发展。

关键词: 传染病, 疾病诊断, 甲状腺, 微流控芯片, 细胞, 性激素, 肿瘤

Abstract: Microfluidic devices exhibit a great promising development in clinical diagnosis and disease screening due to their advantages of precise controlling of fluid flow, requirement of miniamount sample, rapid reaction speed and convenient integration. In this paper, the improvements of microfluidic diagnostic technologies in recent years are reviewed. The applications and developments of on-chip disease marker detection, microfluidic cell selection and cell drug metabolism, and diagnostic micro-devices are discussed.

Key words: cell, disease diagnosis, infectious diseases, microfluidic chip, sex hormone, thyroid, tumor