中药组方指纹图谱研究方法和思路

doi:10.3724/SP.J.1123.2016.02022

摘要/Abstract

摘要：

中药组方就是将单味中药按照一定的规律配伍成方,因剂量配伍差异会导致组方理化性质的改变,从而导致组方功效强弱、性质方面发生变化,甚至产生新的化学成分。中药组方鉴别与质量控制一直是困扰中药工作者的一个难题。指纹图谱技术具有宏观、准确、稳定等优点,已被广泛用于中药领域。中药组方指纹图谱是解决中药合理组方配伍的最有效手段,其对中药质量控制已经得到普遍关注和重视。由于指纹图谱具有整体定量功能和特征性鉴别作用,对于成分复杂的中药组方能够全面地定性与定量评价。本文就中药组方指纹图谱的研究意义与目的进行了综述,并详细阐述了组方指纹图谱的研究方法与思路,以此为中药及其组方指纹图谱研究提供参考。

关键词: 拆方, 中药组方, 组方配伍, 组方指纹图谱

Abstract:

Traditional Chinese medicine (TCM) Composing Prescription is the compatible prescription of Chinese medicinal materials according to certain rules. The differences of its dosage compatibility can often lead to the changes of physical and chemical properties, so that it can change the effects and natures of Composing Prescription and even produce new chemical compositions. So far the identification and quality control of TCM Composing Prescription has been a difficult problem to the medical workers for these reasons. By recent years' development, fingerprint technology has been widely used in TCM research field for having a lot of advantages such as holistic view, accuracy and stability. Composing Prescription fingerprint of TCM is also the most effective control method on solving the problem of the reasonable prescription compatibility of TCM. Now its quality control ability has received wide-spread attention. Fingerprint has both the holistic quantitative function and the characteristic identifiable effects. With these advantages, it could qualitatively, quantitatively and comprehensively evaluate the complicated components of Composing Prescriptions of TCM. In this paper, we review the subject significance and purpose of Composing Prescription fingerprints of TCM, in which we elaborate the study methods and research approach in detail. The main purpose of this paper is to provide a certain reference for TCM and research of the Composing Prescription fingerprints.

Key words: compatible prescription, Composing Prescription fingerprints, Composing Prescription of traditional Chinese medicine, separated prescription

中图分类号:

O658

杨方良, 张晶, 孙国祥, 孙万阳. 中药组方指纹图谱研究方法和思路[J]. 色谱, 2016, 34(7): 715-725.

YANG Fangliang, ZHANG Jing, SUN Guoxiang, SUN Wanyang. Research methods and approach for Composing Prescription fingerprints of traditional Chinese medicine[J]. Chinese Journal of Chromatography, 2016, 34(7): 715-725.

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