色谱

色谱 ›› 2013, Vol. 31 ›› Issue (4): 317-321.DOI: 10.3724/SP.J.1123.2012.10041

• 特别策划：色谱固定相专栏 • 上一篇    下一篇

利用原子转移自由基聚合方法制备一种新型聚合物整体柱固相萃取材料初探

沈莹1,2,齐莉1*,乔娟1,毛兰群1,陈义1   

  1. 1. 中国科学院化学研究所 中国科学院活体分析化学重点实验室, 北京 100190;
    2. 中国科学院大学, 北京 100049
  • 收稿日期:2012-11-12 出版日期:2013-04-22 发布日期:2013-04-24
  • 通讯作者: Tel:(010)82627290,E-mail:qili@iccas.ac.cn
  • 基金资助:

    国家“973计划”项目(2007CB714504);国家自然科学基金项目(21175138,20935005).

Preparation of a novel polymer monolith using atom transfer radical polymerization method for solid phase extraction

SHEN Ying1,2, QI Li1*, QIAO Juan1, MAO Lanqun1, CHEN Yi1   

  1. 1. CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China;2. University of Chinese Academy of Sciences, Beijing 100049, China
  • Received:2012-11-12 Online:2013-04-22 Published:2013-04-24

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摘要：

利用两步原子转移自由基聚合(ATRP)方法,初步建立了新型聚合物整体柱固相萃取(SPE)材料制备的新方法。首先利用ATRP方法,以乙二醇二甲基丙烯酸酯（EDMA）为交联剂,在室温条件下,在滤头中原位快速聚合制备得到负载有聚合物整体柱的萃取装置;然后采用表面诱导的电子转移活化再生原子转移自由基聚合(ARGET ATRP)方法进行表面修饰,得到了聚(二甲基氨基乙基甲基丙烯酸酯)(PDMAEMA)修饰的柱体;进一步将此整体柱用作萃取材料,实现了对激素类药物的富集分析。本研究表明:ATRP有望作为一种简单、有效及反应条件温和的聚合方法用于整体柱的制备,且该方法有潜力实现固相萃取材料在不同装置中的制备。

关键词: 固相萃取, 聚合物整体柱, 原子转移自由基聚合

Abstract:

In this study, a novel polymer monolith based solid phase extraction (SPE) material has been prepared by two-step atom transfer radical polymerization (ATRP) method. Firstly, employing ethylene glycol dimethacrylate (EDMA) as a cross-linker, a polymer monolith filled in a filter head has been in-situ prepared quickly under mild conditions. Then, the activators generated by electron transfer ATRP (ARGET ATRP) was used for the modification of poly(2-(dimethylamino)ethyl-methacrylate) (PDMAEMA) on the monolithic surface. Finally, this synthesized monolith for SPE was successfully applied in the extraction and enrichment of steroids. The results revealed that ATRP can be developed as a facile and effective method with mild reaction conditions for monolith construction and has the potential for preparing monolith in diverse devices.

Key words: atom transfer radical polymerization (ATRP), polymer monolith, solid phase extraction

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