色谱 ›› 2016, Vol. 34 ›› Issue (1): 10-15.DOI: 10.3724/SP.J.1123.2015.10005

• 专论与综述 • 上一篇    下一篇

手性金属有机骨架材料的合成及其在对映异构体选择性分离中的应用

祁晓月, 李先江, 白玉, 刘虎威   

  1. 北京大学化学与分子工程学院, 北京 100871
  • 收稿日期:2015-10-08 出版日期:2016-01-08 发布日期:2012-08-01
  • 通讯作者: 刘虎威
  • 基金资助:

    国家自然科学基金项目(21175008);国家重大科学仪器设备开发专项项目(2013YQ510391).

Synthesis and applications of chiral metal-organic framework in the selective separation of enantiomers

QI Xiaoyue, LI Xianjiang, BAI Yu, LIU Huwei   

  1. College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
  • Received:2015-10-08 Online:2016-01-08 Published:2012-08-01
  • Supported by:

    National Natural Science Foundation of China (Grant No. 21175008); Research Equipment and Facilities Construction Program of the Ministry of Science and Technology of China (Grant No. 2013YQ510391).

摘要:

手性现象在自然界中广泛存在,手性分离在药物研发、农用化学、药理学、环境科学和生物学等诸多领域具有重要意义。手性金属有机骨架化合物材料(MOFs)是一类具有特殊拓扑结构和可设计的孔道结构的新型多孔材料,加之其比表面积高、孔隙率大、热稳定性良好和溶剂耐受性好等特性,使得MOFs在分析化学领域的应用与研究日益深入。本文简要综述了手性MOFs的合成方法,着重讨论了手性MOFs在对映异构体选择性分离方面的应用及相关机理,最后对该类材料的发展前景做了展望。

关键词: 对映异构体, 金属有机骨架化合物, 手性分离, 选择性萃取, 综述

Abstract:

Chirality is a universal phenomenon in nature. Chiral separation is vitally important in drug development, agricultural chemistry, pharmacology, environmental science, biology and many other fields. Chiral metal-organic frameworks (MOFs) are a new group of porous materials with special topology and designable pore structures, as well as their high specific surface area, porosity, excellent thermal stability, solvent resistance, etc. Thus, chiral MOFs are promising with various applications in the field of analytical chemistry. This review summarizes the synthesis strategies of chiral MOFs and their applications in the selective separation of enantiomers, as well as related mechanism.

Key words: chiral separation, enantiomer, metal-organic frameworks, review, selective extraction

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