色谱

色谱 ›› 2024, Vol. 42 ›› Issue (2): 131-141.DOI: 10.3724/SP.J.1123.2023.12018

• 专论与综述 • 上一篇    下一篇

合成酚类化合物的脂代谢干扰效应与致肥胖作用

刘惠楠1,2, 孙振东3, 刘倩1, 周群芳1,2,3,*(), 江桂斌1,2,3   

  1. 1.中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室, 北京 100085
    2.中国科学院大学资源与环境学院, 北京 100049
    3.国科大杭州高等研究院环境学院, 浙江 杭州 310024
  • 收稿日期:2023-12-17 出版日期:2024-02-08 发布日期:2024-02-20
  • 通讯作者: * Tel:(010)62849334,E-mail:zhouqf@rcees.ac.cn.
  • 基金资助:
    国家自然科学基金(22193050);国家自然科学基金(22176204);浙江省自然科学基金(LQ24B070004)

Synthetic phenolic compounds perturb lipid metabolism and induce obesogenic effects

LIU Huinan1,2, SUN Zhendong3, LIU Qian S.1, ZHOU Qunfang1,2,3,*(), JIANG Guibin1,2,3   

  1. 1. State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
    2. College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, China
    3. School of Environment, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China
  • Received:2023-12-17 Online:2024-02-08 Published:2024-02-20
  • Supported by:
    National Natural Science Foundation of China(22193050);National Natural Science Foundation of China(22176204);Zhejiang Natural Science Foundation of China(LQ24B070004)

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摘要：

随着社会经济的不断发展,肥胖已经成为一种不可忽视的全球性流行疾病。除了受到遗传和饮食因素的影响外,肥胖的形成与发展也与环境中的化学物质暴露有关。研究发现一些具有内分泌干扰活性的化学物质可以影响机体脂代谢,如促进脂肪细胞形成、引起体内脂质累积增加等,这类物质被称为“环境致肥胖物质”。合成酚类化合物广泛用于工业生产和日常生活用品中,如塑料制品、消毒剂、杀虫剂和食品添加剂等,它们可通过饮食、饮水或皮肤接触等方式进入人体,是影响人体健康的潜在威胁。研究显示,合成酚类化合物具有内分泌干扰效应,可以影响脂肪生成过程、干扰脂代谢,具有致肥胖作用。由于这类物质都具有类似的苯酚结构,因此系统梳理这类化合物脂代谢干扰效应与致肥胖作用,有助于理解其构效关系与潜在健康风险。本文阐述了筛选环境致肥胖物质的3种常用研究模型,即体外分子互作研究模型、细胞成脂分化模型和动物脂代谢实验模型,并比较了各种模型的适用场景和优缺点。在此基础上,针对3种合成酚类化合物,即双酚A及其类似物、烷基酚和酚类抗氧化剂,结合其体外细胞与动物实验数据,对这些化合物的暴露现状和脂代谢干扰效应进行了分类描述,从它们对脂肪生成和代谢、肝组织脂代谢的影响等方面展开讨论。基于近年来脂代谢和致肥胖效应的相关研究,本文归纳总结了环境内分泌干扰物干扰脂代谢的内在毒理机制,主要包括核受体调控作用、炎症和氧化应激、肠道微环境、表观遗传和其他信号通路。最后本文指出了当前针对环境污染物,特别是新污染物,影响机体脂代谢引起肥胖效应研究中的不足,并对该领域研究进行了展望。

关键词: 合成酚类化合物, 肥胖, 环境致肥胖物质, 脂代谢, 综述

Abstract:

Given continuous development in society and the economy, obesity has become a global epidemic, arousing great concern. In addition to genetic and dietary factors, exposure to environmental chemicals is associated with the occurrence and development of obesity. Current research has indicated that some chemicals with endocrine-disrupting effects can affect lipid metabolism in vivo, causing elevated lipid storage. These chemicals are called “environmental obesogens”. Synthetic phenolic compounds (SPCs) are widely used in industrial and daily products, such as plastic products, disinfectants, pesticides, food additives, and so on. The exposure routes of SPCs to the human body may include food and water consumption, direct skin contact, etc. Their unintended exposure could cause harmful effects on human health. As a type of endocrine disruptor, SPCs interfere with adipogenesis and lipid metabolism, exhibiting the characteristics of environmental obesogens. Because SPCs have similar phenolic structures, gathering information on their influences on lipid metabolism would be helpful to understand their structure-related effects. In this review, three commonly used research methods for screening environmental obesogens, including in vitro testing for molecular interactions, cell adipogenic differentiation models, and in vivo studies on lipid metabolism, are summarized, and the advantages and disadvantages of these methods are compared and discussed. Based on both in vitro and in vivo data, three types of SPCs, including bisphenol A (BPA) and its analogues, alkylphenols (APs), and synthetic phenolic antioxidants (SPAs), are systematically discussed in terms of their ability to disrupt adipogenesis and lipid metabolism by focusing on adipose and hepatic tissues, among others. Common findings on the effects of these SPCs on adipocyte differentiation, lipid storage, hepatic lipid accumulation, and liver steatosis are described. The underlying toxicological mechanisms are also discussed from the aspects of nuclear receptor transactivation, inflammation and oxidative stress regulation, intestinal microenvironment alteration, epigenetic modification, and some other signaling pathways. Future research to increase public knowledge on the obesogenic effects of emerging chemicals of concern is encouraged.

Key words: synthetic phenolic compounds (SPCs), obesity, environmental obesogen, lipid metabolism, review

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