色谱 ›› 2016, Vol. 34 ›› Issue (1): 113-118.DOI: 10.3724/SP.J.1123.2015.08001

• 研究论文 • 上一篇    

单手螺旋三维骨架材料[{Cu(sala)}n]混合全戊基-β-环糊精用于促进气相色谱对映选择分离

谢生明1, 刘虹2, 杨江蓉3, 艾萍1, 袁黎明1   

  1. 1. 云南师范大学化学化工学院, 云南 昆明 650500;
    2. 楚雄州食品药品检验所, 云南 楚雄 675000;
    3. 德宏职业学院, 云南 德宏 678400
  • 收稿日期:2015-08-01 出版日期:2016-01-08 发布日期:2012-08-01
  • 通讯作者: 袁黎明
  • 基金资助:

    国家自然科学基金项目(21275126, 21365024);云南省应用基础研究计划项目(2013FB035).

Single-handed helical framework material [{Cu(sala)}n] incorporated peramylated β-cyclodextrin for improving gas chromatography enantioseparation

XIE Shengming1, LIU Hong2, YANG Jiangrong3, AI Ping1, YUAN Liming1   

  1. 1. School of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China;
    2. Chuxiong Institute for Food and Drug Control, Chuxiong 675000, China;
    3. Dehong Vocational College, Dehong 678400, China
  • Received:2015-08-01 Online:2016-01-08 Published:2012-08-01
  • Supported by:

    National Natural Science Foundation (21275126, 21365024); Yunnan Province's Basic Research Program (2013FB035).

摘要:

手性金属-有机骨架材料(metal-organic frameworks, MOFs)作为一种新型的功能材料,因其具有高比表面积、丰富的拓扑结构、持久性的孔结构以及可修饰的孔道表面等特点,在对映选择性催化和手性分离方面有着广阔的应用前景。本文将一种单手螺旋三维金属-有机骨架材料[{Cu(sala)}n](H2sala=N-(2-hydroxybenzyl)-L-alanine)与全戊基-β-环糊精混合,制备了新型毛细管气相色谱固定相。为了考察手性MOF是否能够增强全戊基-β-环糊精的手性分离能力,分别用不同的固定相制备了3根手性柱用于对比:柱A([{Cu(sala)}n])、柱B(全戊基-β-环糊精)和柱C([{Cu(sala)}n]+全戊基-β-环糊精)。比较了柱A、柱B和柱C对相同手性化合物的拆分能力,结果表明柱C具有更好的手性选择性和更高的分辨能力,证实使用MOF [{Cu(sala)}n]能够提高全戊基-β-环糊精的对映选择分离能力。

关键词: -环糊精, 固定相, 金属-有机骨架材料, 毛细管柱, 气相色谱, 全戊基-&beta, 手性分离

Abstract:

Metal-organic frameworks (MOFs) as a new generation of functional molecular materials, have broad application prospects in enantioselective catalysis and chiral separation areas due to their unusual properties, such as high surface area, rich topologies, permanent microporous, availability of outer-surface modification and so on. A single-handed helical three-dimensional metal-organic framework material [{Cu(sala)}n] (H2sala=N-(2-hydroxybenzyl)-L-alanine) was incorporated with peramylated β-cyclodextrin for the preparation of novel capillary gas chromatography stationary phase. To investigate whether the use of a chiral MOF can enhance enantioseparation on peramylated β-cyclodextrin, three chiral columns were fabricated using different stationary phases for comparison, including column A ([{Cu(sala)}n]), column B (peramylated β-cyclodextrin) and column C ([{Cu(sala)}n]+peramylated β-cyclodextrin). The results of comparing the resolving abilities of the three columns for the same chiral compounds demonstrated that column C showed better enantioselectivity and higher resolution. The use of MOF [{Cu(sala)}n] can improve enantioseparation on peramylated β-cyclodextrin.

Key words: capillary column, chiral separation, gas chromatography (GC), metal-organic frameworks (MOFs), peramylated β-cyclodextrin, stationary phase

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