色谱

色谱 ›› 2012, Vol. 30 ›› Issue (01): 95-98.DOI: 10.3724/SP.J.1123.2011.08030

• 技术与应用 • 上一篇    下一篇

液相色谱-串联质谱法测定小型家用电器塑料部件中双酚A

张岩2, 马晓斐2, 吕品3, 李挥2, 卢晓宇1*   

  1. 1. 北京出入境检验检疫局, 北京 100026; 2. 河北省食品质量监督检验研究院, 河北 石家庄 050091; 3. 河北医科大学, 河北 石家庄 050017
  • 收稿日期:2011-08-22 修回日期:2011-10-09 出版日期:2012-01-28 发布日期:2012-03-01
  • 通讯作者: 卢晓宇,工程师,主要从事化学危险品安全性评价技术的研究. Tel: (010)58619228,
  • 基金资助:
    国家质检总局科技计划项目(2009IK100).

Determination of bisphenol A in plastic parts of small household appliances by liquid chromatography-tandem mass spectrometry

ZHANG Yan2, MA Xiaofei2, Lv Pin3, LI Hui2, LU Xiaoyu1*   

  1. 1. Beijing Entry-Exit Inspection and Quarantine Bureau, Beijing 100026, China; 2. Hebei Institute of Food Quality Supervision Inspection and Research, Shijiazhuang 050091, China; 3. Hebei Medical University, Shijiazhuang 050017, China
  • Received:2011-08-22 Revised:2011-10-09 Online:2012-01-28 Published:2012-03-01

PDF

429

被引次数

24

摘要： 建立了小型家用电器塑料部件中双酚A的液相色谱-串联质谱(LC-MS/MS)检测方法。采用快速溶剂萃取仪对样品进行萃取,以Sep-Pak C18固相萃取柱净化,甲醇-水(含有0.05%氨水)混合液作为流动相,负离子模式下进行MS/MS检测。结果表明: 该方法在5～100 μg/L范围内线性关系良好,相关系数(r2)为0.9991。在10、25和75 μg/kg 3个添加水平下,双酚A的平均回收率为95.2%～109.7%,相对标准偏差均小于3.8%,检出限为10 μg/kg。该方法操作简便,灵敏度高,适用于家用电器塑料部件中双酚A的残留分析。

关键词: 固相萃取, 家用电器, 双酚A, 塑料部件, 液相色谱-串联质谱

Abstract: A method for the determination of bisphenol A in the plastic parts of small household appliances by liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed. The sample was extracted with accelerated solvent extraction (ASE) and purified by Sep-Pak C18 solid phase extraction. Bisphenol A was separated and detected using LC-MS/MS in negative ion mode with the mobile phases of methanol and water (containing 0.05% ammonia water). The linearity of the method was good in the range of 5 μg/L to 100 μg/L. The recoveries for the spiked sample were from 95.2% to 109.7% at the three levels, 10, 25 and 75 μg/kg. The relative standard deviations were less than 3.8%. The limit of detection was 10 μg/kg. The method is easy-handling, time-saving, sensitive and suitable for the determination of the residual bisphenol A in the plastic parts of household appliances.

Key words: bisphenol A, household appliances, plastic parts, solid phase extraction (SPE), liquid chromatography-tandem mass spectrometry (LC-MS/MS)