色谱

色谱 ›› 2016, Vol. 34 ›› Issue (5): 490-497.DOI: 10.3724/SP.J.1123.2015.12006

• 研究论文 • 上一篇    下一篇

盐酸特拉唑嗪降解产物的结构鉴定

孙玉明1, 李英1, 王月月1, 张华1, 王玉林2   

  1. 1. 大连理工大学化工学院, 辽宁 大连 116024;
    2. 大连医科大学基础医学院, 辽宁 大连 116044
  • 收稿日期:2015-12-07 出版日期:2016-05-08 发布日期:2012-12-18
  • 通讯作者: 王玉林

Structure characterization of the degradation products of terazosin hydrochloride

SUN Yuming1, LI Ying1, WANG Yueyue1, ZHANG Hua1, WANG Yulin2   

  1. 1. School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China;
    2. Basic Medical College, Dalian Medical University, Dalian 116044, China
  • Received:2015-12-07 Online:2016-05-08 Published:2012-12-18

PDF

126

被引次数

2

摘要：

盐酸特拉唑嗪是一种新型选择性 α1-肾上腺能受体拮抗剂,用于治疗高血压和良性前列腺增生。采用高效液相色谱-高分辨多级质谱(HPLC-HRMSn)联用法对强氧化条件下盐酸特拉唑嗪原料药的降解产物进行了详细的解析和结构确证。共检测到15种降解产物,其中7种与文献报道的有关物质相同,另外8种为新检测到的降解产物,其主要降解途径为酰胺键水解、羟基化、羰基化及3种途径组合的次级降解途径。

关键词: 高效液相色谱-高分辨多级质谱, 降解产物, 结构鉴定, 盐酸特拉唑嗪

Abstract:

Terazosin hydrochloride is a selective α1-adrenergic blocker used in the treatment of hypertension and benign prostatic hyperplasia. A high performance liquid chromatography-multistage mass spectrometry with high resolution (HPLC-HRMSn) method was used to detect and identify the degradation products of terazosin hydrochloride treated under stressed oxidation condition. There were 15 degradation products detected. Seven of them were the same as those found in the related references, and the other eight of them were newly found and identified. The main degradation pathways are the hydrolysis of amide bond, hydroxylation, carbonylation and secondary degradation pathways by the combination of the above three ways.

Key words: degradation products, high performance liquid chromatography-multistage mass spectrometry with high resolution (HPLC-HRMSn), structure characterization, terazosin hydrochloride

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