双手性选择单元手性固定相的研究进展

doi:10.3724/SP.J.1123.2016.06013

色谱 ›› 2016, Vol. 34 ›› Issue (9): 831-834.DOI: 10.3724/SP.J.1123.2016.06013

双手性选择单元手性固定相的研究进展

崔冬晓^1,2, 贾艳艳², 李广庆³, 文爱东², 王西芳¹

1. 陕西中医药大学药学院, 陕西咸阳 712046;
2. 第四军医大学西京医院药剂科, 陕西西安 710032;
3. 迪马科技公司, 北京 100029

收稿日期:2016-06-08 出版日期:2016-09-08 发布日期:2016-08-26
通讯作者: 王西芳
基金资助:
国家自然科学基金项目（81503028）；国家科技支撑计划项目（2015BAK45B01）.

Advances in chiral stationary phases with dual chiral selectors

CUI Dongxiao^1,2, JIA Yanyan², LI Guangqing³, WEN Aidong², WANG Xifang¹

1. College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China;
2. Department of Pharmacy, Xijing Hospital, the Fourth Military Medical University, Xi'an 710032, China;
3. Dikma Technologies Inc., Beijing 100029, China

Received:2016-06-08 Online:2016-09-08 Published:2016-08-26
Supported by:
the National Natural Science Fund(No. 81503028); National Key Technology Support Program(No. 2015BAK45B01).

摘要/Abstract

摘要：

手性固定相（chiral stationary phase，CSP）作为手性色谱分离的核心技术，在手性化合物的识别和分离中得到广泛应用。以双手性选择单元结合作为CSP是近些年的研究热点，研究表明，两种手性选择单元相结合的CSP可增加手性识别位点，显著提高分离效果。本文介绍了近几年双手性选择单元手性固定相在手性分离中的研究进展，并对其发展前景进行了展望。

关键词: 手性分离, 手性固定相, 双手性选择单元

Abstract:

The chiral stationary phases (CSPs) as core technology play important roles in the identification and separation of chiral compounds. The CSPs with dual chiral selectors become the main issue in recent years. Many studies indicate that CSPs containing two efficient chiral selectors increase chiral recognition sites, and exhibit good chiral separation performance. This paper introduces chiral stationary phases with dual chiral selectors in the research development of chiral separation in recent years, and the development prospects are also discussed.

Key words: chiral separation, chiral stationary phases, dual chiral selectors

中图分类号:

O658

崔冬晓, 贾艳艳, 李广庆, 文爱东, 王西芳. 双手性选择单元手性固定相的研究进展[J]. 色谱, 2016, 34(9): 831-834.

CUI Dongxiao, JIA Yanyan, LI Guangqing, WEN Aidong, WANG Xifang. Advances in chiral stationary phases with dual chiral selectors[J]. Chinese Journal of Chromatography, 2016, 34(9): 831-834.

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双手性选择单元手性固定相的研究进展

Advances in chiral stationary phases with dual chiral selectors

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