色谱 ›› 2016, Vol. 34 ›› Issue (11): 1022-1030.DOI: 10.3724/SP.J.1123.2016.07018

• 专论与综述 • 上一篇    下一篇

聚多巴胺表面改性技术在分离科学领域中的应用

柴微波1, 王会娟1, 安学涵1, 丁国生1,2,3   

  1. 1. 天津大学药物科学与技术学院, 天津 300072;
    2. 药物化学生物学国家重点实验室(南开大学), 天津 300071;
    3. 天津大学分析测试中心, 天津 300072
  • 收稿日期:2016-07-15 出版日期:2016-11-08 发布日期:2016-11-03
  • 通讯作者: 丁国生
  • 基金资助:

    国家自然科学基金(21005054);药物化学生物学国家重点实验室开放基金(201603004).

Applications of polydopamine surface modification technique in separation science

CHAI Weibo1, WANG Huijuan1, AN Xuehan1, DING Guosheng1,2,3   

  1. 1. School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China;
    2. State Key Laboratory of Medicinal Chemical Biology(Nankai University), Tianjin 300071, China;
    3. Analysis Center, Tianjin University, Tianjin 300072, China
  • Received:2016-07-15 Online:2016-11-08 Published:2016-11-03
  • Supported by:

    National Natural Science Foundation of China (No. 21005054); State Key Laboratory of Medicinal Chemical Biology (No. 201603004).

摘要:

聚多巴胺作为新型仿生材料,具有制备过程简单、环保和适用面广(可用于各种类型基质表面改性)等优点,已被广泛应用于化学、生物医学、药学、传感器和电池制造等领域。在分离科学领域,聚多巴胺不仅可用于制备色谱固定相,也可用于制备新型的富集材料。该文对聚多巴胺的形成机理研究现状进行了简单介绍,主要综述了近年来聚多巴胺在色谱分离和富集领域的应用,包括毛细管电泳/电色谱、液相色谱、分子印迹固相萃取、分散固相微萃取和固相微萃取等技术领域。

关键词: 富集, 聚多巴胺, 色谱分离, 综述

Abstract:

As a novel bio-inspired material, polydopamine (PDA) coatings are easily formed in environmentally friendly conditions on virtually all kinds of inorganic and organic substrates. PDA has been applied in many areas such as chemical, biomedical, pharmaceutical, sensor and battery manufacturing, etc. In the field of separation science, PDA can be used to prepare new enrichment materials, as well as stationary phases for chromatographic separation. In this review, the research status of the formation mechanism of PDA is introduced firstly; emphases are put on the recent applications of PDA in the areas of separation and enrichment, such as capillary electrophoresis, liquid chromatography, molecularly imprinted solid-phase extraction, dispersive solid-phase microextraction and solid phase microextraction, etc.

Key words: chromatographic separation, enrichment, polydopamine (PDA), review

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