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BORONIC ACIDS AS LIGANDS FOR AFFINITY CHROMATOGRAPHY

刘小川   

  1. Department of Chemistry, California State Polytechnic University, Pomona, CA 91768, USA
  • 收稿日期:2005-12-31 修回日期:1900-01-01 出版日期:2006-01-30 发布日期:1987-09-25
  • 通讯作者: 刘小川

BORONIC ACIDS AS LIGANDS FOR AFFINITY CHROMATOGRAPHY

Xiao-Chuan Liu   

  1. Department of Chemistry, California State Polytechnic University, Pomona, CA 91768, USA
  • Received:2005-12-31 Revised:1900-01-01 Online:2006-01-30 Published:1987-09-25
  • Contact: Xiao-Chuan Liu

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摘要： A review on the principles and applications of boronic acids as affinity ligands for the chromatographic separation of carbohydrates, nucleic acid components, glycoproteins, and other small biomolecules. The mechanisms of interactions between boronate ligands and analytes are described. Various boronate ligands and supports are discussed. Examples of the use of boronate affinity chromatography for separation of each class of analytes are presented.

关键词: borate, boronate, boronate affinity chromatography, boronic acids, separation of glycoproteins

Abstract: A review on the principles and applications of boronic acids as affinity ligands for the chromatographic separation of carbohydrates, nucleic acid components, glycoproteins, and other small biomolecules. The mechanisms of interactions between boronate ligands and analytes are described. Various boronate ligands and supports are discussed. Examples of the use of boronate affinity chromatography for separation of each class of analytes are presented.

Key words: borate, boronate, boronate affinity chromatography, boronic acids, separation of glycoproteins