色谱

色谱

• 兴奋剂检测方法专栏 • 上一篇    下一篇

基因兴奋剂检测的现状与展望

王文珺1,张四纯1,徐静娟2,夏兴华2,田亚平3,张新荣1,陈洪渊2   

  1. 1.Department of Chemistry, Tsinghua University, Beijing 100084, China; 2.School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China; 3.Department of Clinical Biochemistry, General Hospital of Chinese People’s Liberation Army, Beijing 100853, China
  • 收稿日期:2008-01-05 修回日期:2008-07-30 出版日期:2008-07-30 发布日期:1983-12-25
  • 通讯作者: 陈洪渊
  • 基金资助:
    国家自然科学基金重点项目“基因兴奋剂的检测方法研究”(No. 20635002)资助.

Current status and prospects of gene doping detection

WANG Wenjun1, ZHANG Sichun1, XU Jingjuan2, XIA Xinghua2, TIAN Yaping3, ZHANG Xinrong1, CHEN Hong-Yuan2   

  1. 1.Department of Chemistry, Tsinghua University, Beijing 100084, China; 2.School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China; 3.Department of Clinical Biochemistry, General Hospital of Chinese People’s Liberation Army, Beijing 100853, China
  • Received:2008-01-05 Revised:2008-07-30 Online:2008-07-30 Published:1983-12-25
  • Contact: CHEN Hong-Yuan

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摘要： 生物技术在取得巨大成就的同时也导致了兴奋剂的发展。从体外重组蛋白到潜在的基因兴奋剂的出现,给兴奋剂检测工作带来了巨大的挑战。基因治疗的发展以及一些功能基因对运动技能提高的潜力,加大了基因兴奋剂使用的可能性。本文在介绍基因兴奋剂的基础上,阐述了基因兴奋剂检测方法的研究现状,展望了基因兴奋剂检测技术的发展策略。

关键词: 促红细胞生长素, 基因兴奋剂, 基因治疗, 兴奋剂检测, 胰岛素样生长因子-I

Abstract: The fast development of biotechnology promotes the development of doping. From recombinant protein to gene doping, there is a great challenge to their detection. The improvement of gene therapy and potential to enhance athletic performance open the door for gene doping. After a brief introduction of the concept of gene doping, the current status and prospects of gene doping detection are reviewed.

Key words: erythropoietin, gene doping, gene therapy, insulin-like growth factor-I (IGF-I) , doping detection