Abstract: The fast development of biotechnology promotes the development of doping. From recombinant protein to gene doping, there is a great challenge to their detection. The improvement of gene therapy and potential to enhance athletic performance open the door for gene doping. After a brief introduction of the concept of gene doping, the current status and prospects of gene doping detection are reviewed.

Key words: erythropoietin, gene doping, gene therapy, insulin-like growth factor-I (IGF-I) , doping detection