Chinese Journal of Chromatography ›› 2016, Vol. 34 ›› Issue (1): 4-9.DOI: 10.3724/SP.J.1123.2015.10037

• Communications • Previous Articles     Next Articles

Synthesis of novel glucose-based polymers and their applications as chiral stationary phases for high performance liquid chromatography

Tomoyuki IKAI, Takayuki YAMADA   

  1. Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan
  • Received:2015-10-26 Online:2016-01-08 Published:2012-08-01
  • Contact: Tomoyuki IKAI
  • Supported by:

    This work was supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI Grants-in-Aid for Scientific Research (C) (Grant No. 26410129).

Abstract:

Two novel polymers containing glucose units as the main-chain that only differ in terms of their regioregularity were synthesized to evaluate their chiral recognition abilities as chiral stationary phases (CSPs) for high performance liquid chromatography (HPLC). The regioregular polymer (poly-5) shows clear resolution ability for the racemate of cobalt (Ⅲ) acetylacetonate (Co(acac)3), whereas the corresponding regioirregular polymer (poly-3) does not show any chiral recognition for Co(acac)3. The regioregular polymer main-chain seems to play an important role not only in providing an efficient interaction with the racemate but also in expressing the chiral recognition ability as a CSP for HPLC.

Key words: biomass, chiral discrimination, chirality, enantioseparation, glucose, regioregularity

CLC Number: