Abstract: Liposome capillary electrophoresis (LCE) was used as a model for the in vitro evaluation of the degree of membrane penetration of organic compounds. The hydrophobic parameters of 9 compounds were determined by LCE. In comparison of the correlation coefficient of log Plw ( the logarithm of the partition coefficient of liposome/water system, calculated from retention factor) vs. log Pm (the logarithm of osmotic coefficient) with that of log Pow (the logarithm of the partition coefficient of octanol/water system) vs. log Pm, the former was 0.94, much greater than the latter 0.78. It means that as the biomembrane model, liposome is more similar than the octanol/water system. The LCE method has the potential to be an in vitro screening model.

Key words: absorption in human body, hydrophobic parameter, organic compounds, permeability coefficient, prediction , liposome capillary electrophoresis