Chinese Journal of Chromatography ›› 2022, Vol. 40 ›› Issue (12): 1102-1110.DOI: 10.3724/SP.J.1123.2022.07021
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LU Shaoming1,2, XU Xin1,2,3, XUE Qianqian1,2, XIAO Liujun1,2, YU Wenyi1,2,4, WEI Tong4, JIN Hongli1,2,3,4,*(), LIU Yanfang1,2,3,4, LIANG Xinmiao1,2,3,4
Received:
2022-07-27
Online:
2022-12-08
Published:
2022-11-29
Contact:
JIN Hongli
Supported by:
CLC Number:
LU Shaoming, XU Xin, XUE Qianqian, XIAO Liujun, YU Wenyi, WEI Tong, JIN Hongli, LIU Yanfang, LIANG Xinmiao. Quality evaluation of Fufang Jinqiancao granules based on ultra performance liquid chromatography-ultraviolet detection quantitative fingerprint combined with chemical pattern recognition[J]. Chinese Journal of Chromatography, 2022, 40(12): 1102-1110.
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URL: https://www.chrom-china.com/EN/10.3724/SP.J.1123.2022.07021
No. | Lot number | Size/ (g/bag) | No. | Lot number | Size/ (g/bag) |
---|---|---|---|---|---|
S1 | 180306/1 | 3 | S19 | 191107/2 | 10 |
S2 | 180401/3 | 3 | S20 | 200313/1 | 3 |
S3 | 181121/2 | 3 | S21 | 200603/1 | 3 |
S4 | 180126/1 | 10 | S22 | 201005/1 | 3 |
S5 | 180304/1 | 10 | S23 | 201128/1 | 3 |
S6 | 180411/1 | 10 | S24 | 200411/1 | 10 |
S7 | 180517/2 | 10 | S25 | 200528/2 | 10 |
S8 | 180929/1 | 10 | S26 | 200613/1 | 10 |
S9 | 181109/2 | 10 | S27 | 201015/2 | 10 |
S10 | 190213/1 | 3 | S28 | 210106/1 | 3 |
S11 | 190326/1 | 3 | S29 | 210220/2 | 3 |
S12 | 190522/2 | 3 | S30 | 210503/1 | 3 |
S13 | 190722/1 | 3 | S31 | 210716/1 | 3 |
S14 | 190120/1 | 10 | S32 | 210122/2 | 10 |
S15 | 190426/1 | 10 | S33 | 210223/2 | 10 |
S16 | 190525/2 | 10 | S34 | 210505/1 | 10 |
S17 | 190618/2 | 10 | S35 | 210623/1 | 10 |
S18 | 190718/2 | 10 | S36 | 201026/2 | 10 |
Table 1 Sample information for 36 batches of Fufang Jinqiancao granules
No. | Lot number | Size/ (g/bag) | No. | Lot number | Size/ (g/bag) |
---|---|---|---|---|---|
S1 | 180306/1 | 3 | S19 | 191107/2 | 10 |
S2 | 180401/3 | 3 | S20 | 200313/1 | 3 |
S3 | 181121/2 | 3 | S21 | 200603/1 | 3 |
S4 | 180126/1 | 10 | S22 | 201005/1 | 3 |
S5 | 180304/1 | 10 | S23 | 201128/1 | 3 |
S6 | 180411/1 | 10 | S24 | 200411/1 | 10 |
S7 | 180517/2 | 10 | S25 | 200528/2 | 10 |
S8 | 180929/1 | 10 | S26 | 200613/1 | 10 |
S9 | 181109/2 | 10 | S27 | 201015/2 | 10 |
S10 | 190213/1 | 3 | S28 | 210106/1 | 3 |
S11 | 190326/1 | 3 | S29 | 210220/2 | 3 |
S12 | 190522/2 | 3 | S30 | 210503/1 | 3 |
S13 | 190722/1 | 3 | S31 | 210716/1 | 3 |
S14 | 190120/1 | 10 | S32 | 210122/2 | 10 |
S15 | 190426/1 | 10 | S33 | 210223/2 | 10 |
S16 | 190525/2 | 10 | S34 | 210505/1 | 10 |
S17 | 190618/2 | 10 | S35 | 210623/1 | 10 |
S18 | 190718/2 | 10 | S36 | 201026/2 | 10 |
Fig. 2 UPLC reference fingerprints of Fufang Jinqiancao granules 1. mangiferin; 2. isomangiferin; 3. vicenin-2; 4. vicenin 3 isomer, kaempferol-3-O-β-D-glucopyranosyl-7-O-β-D-apioside; 5. isoorientin; 6. orientin; 7. schaftoside; 8. vicenin 3 isomer; 9. vicenin 3; 10. isovitexin; 11. acteoside; 12. plantamajoside.
No. | Adduct ion | MS (m/z) | MS/MS (m/z) | Identification | Medicine |
---|---|---|---|---|---|
1* | [M+H]+ | 423.0969 | 405.0813, 387.0701, 369.0599, 357.0597, 327.0496, 303.0498, 273.0392, 261.0386 | mangiferin[ | GSW |
2* | [M+H]+ | 423.0962 | 405.0809, 387.0708, 369.0599, 357.0600, 327.0495, 303.0497, 273.0390, 261.0385 | isomangiferin[ | GSW |
3* | [M+H]+ | 595.1653 | 559.1417, 541.1321, 457.1122, 379.0803, 337.0698, 325.0694 | vicenin-2[ | GJQC |
4 | [M+H]+ | 565.1549 | 547.1441, 529.1330, 511.1224, 499.1219, 493.1121, 475.1218, 457.1100, 445.0879, 427.1018, 409.0911, 379.0817, 349.0682, 325.0695 | vicenin 3 isomer[ | GJQC |
[M+H]+ | 581.1497 | 563.1407, 545.1272, 527.1183, 515.1149, 497.1050, 473.1063, 461.1066, 455.0937, 443.0955 | kaempferol-3-O-β-D- glucopyranosyl-7-O- β-D-apioside[ | GSW | |
5* | [M+H]+ | 449.1073 | 431.0955, 413.0846, 395.0740, 383.0736, 353.0645, 329.0649, 299.0545 | isoorientin[ | GJQC/YMX |
6 | [M+H]+ | 449.1074 | 431.0964, 413.0858, 395.0765, 353.0643, 329.0639, 299.0536 | orientin[ | GJQC/YMX |
7* | [M+H]+ | 565.1557 | 547.1433, 529.1325, 511.1233, 499.1224, 493.1118, 469.1125, 457.1117, 445.1114, 427.1022, 409.0909, 397.0912, 379.0798, 349.0692, 325.0709 | schaftoside[ | GJQC |
8 | [M+H]+ | 565.1549 | 547.1438, 529.1321, 511.1232, 499.1222, 493.1124, 469.1115, 457.1128, 445.1124, 427.1022, 409.0909, 397.0912, 379.0798, 349.0692, 325.0709 | vicenin 3 isomer[ | GJQC |
9* | [M+H]+ | 565.1551 | 547.1445, 529.1333, 511.1226, 499.1223, 493.1124, 469.1120, 457.1116, 445.1128, 427.1014, 409.0913, 397.0915, 379.0811, 325.0692 | vicenin 3[ | GJQC |
10* | [M+H]+ | 433.1128 | 415.1011, 397.0905, 379.0809, 367.0817, 337.0702, 313.0696, 283.0592 | isovitexin[ | YMX |
11* | [M-H]- | 623.1975 | 461.1651, 179.0349, 161.0243, 135.0449, 113.0244, 89.0244, 71.0141 | acteoside[ | CQC |
12 | [M-H]- | 639.1930 | 477.1602, 315.1091, 161.0242, 443.0241, 71.0137 | plantamajoside[ | CQC |
Table 2 Identification of characteristic peaks of Fufang Jinqiancao granule fingerprints
No. | Adduct ion | MS (m/z) | MS/MS (m/z) | Identification | Medicine |
---|---|---|---|---|---|
1* | [M+H]+ | 423.0969 | 405.0813, 387.0701, 369.0599, 357.0597, 327.0496, 303.0498, 273.0392, 261.0386 | mangiferin[ | GSW |
2* | [M+H]+ | 423.0962 | 405.0809, 387.0708, 369.0599, 357.0600, 327.0495, 303.0497, 273.0390, 261.0385 | isomangiferin[ | GSW |
3* | [M+H]+ | 595.1653 | 559.1417, 541.1321, 457.1122, 379.0803, 337.0698, 325.0694 | vicenin-2[ | GJQC |
4 | [M+H]+ | 565.1549 | 547.1441, 529.1330, 511.1224, 499.1219, 493.1121, 475.1218, 457.1100, 445.0879, 427.1018, 409.0911, 379.0817, 349.0682, 325.0695 | vicenin 3 isomer[ | GJQC |
[M+H]+ | 581.1497 | 563.1407, 545.1272, 527.1183, 515.1149, 497.1050, 473.1063, 461.1066, 455.0937, 443.0955 | kaempferol-3-O-β-D- glucopyranosyl-7-O- β-D-apioside[ | GSW | |
5* | [M+H]+ | 449.1073 | 431.0955, 413.0846, 395.0740, 383.0736, 353.0645, 329.0649, 299.0545 | isoorientin[ | GJQC/YMX |
6 | [M+H]+ | 449.1074 | 431.0964, 413.0858, 395.0765, 353.0643, 329.0639, 299.0536 | orientin[ | GJQC/YMX |
7* | [M+H]+ | 565.1557 | 547.1433, 529.1325, 511.1233, 499.1224, 493.1118, 469.1125, 457.1117, 445.1114, 427.1022, 409.0909, 397.0912, 379.0798, 349.0692, 325.0709 | schaftoside[ | GJQC |
8 | [M+H]+ | 565.1549 | 547.1438, 529.1321, 511.1232, 499.1222, 493.1124, 469.1115, 457.1128, 445.1124, 427.1022, 409.0909, 397.0912, 379.0798, 349.0692, 325.0709 | vicenin 3 isomer[ | GJQC |
9* | [M+H]+ | 565.1551 | 547.1445, 529.1333, 511.1226, 499.1223, 493.1124, 469.1120, 457.1116, 445.1128, 427.1014, 409.0913, 397.0915, 379.0811, 325.0692 | vicenin 3[ | GJQC |
10* | [M+H]+ | 433.1128 | 415.1011, 397.0905, 379.0809, 367.0817, 337.0702, 313.0696, 283.0592 | isovitexin[ | YMX |
11* | [M-H]- | 623.1975 | 461.1651, 179.0349, 161.0243, 135.0449, 113.0244, 89.0244, 71.0141 | acteoside[ | CQC |
12 | [M-H]- | 639.1930 | 477.1602, 315.1091, 161.0242, 443.0241, 71.0137 | plantamajoside[ | CQC |
No. | Similarity | No. | Similarity |
---|---|---|---|
S1 | 0.999 | S19 | 0.997 |
S2 | 0.995 | S20 | 0.996 |
S3 | 0.999 | S21 | 0.996 |
S4 | 0.954 | S22 | 0.993 |
S5 | 0.952 | S23 | 0.987 |
S6 | 0.966 | S24 | 0.999 |
S7 | 0.968 | S25 | 0.990 |
S8 | 0.989 | S26 | 0.993 |
S9 | 0.990 | S27 | 0.999 |
S10 | 0.989 | S28 | 0.996 |
S11 | 0.998 | S29 | 0.996 |
S12 | 0.996 | S30 | 0.995 |
S13 | 0.993 | S31 | 0.989 |
S14 | 0.981 | S32 | 0.998 |
S15 | 0.972 | S33 | 0.998 |
S16 | 0.992 | S34 | 0.996 |
S17 | 0.995 | S35 | 0.992 |
S18 | 0.991 |
Table 3 Similarity evaluation for the 35 batches of Fufang Jinqiancao granules
No. | Similarity | No. | Similarity |
---|---|---|---|
S1 | 0.999 | S19 | 0.997 |
S2 | 0.995 | S20 | 0.996 |
S3 | 0.999 | S21 | 0.996 |
S4 | 0.954 | S22 | 0.993 |
S5 | 0.952 | S23 | 0.987 |
S6 | 0.966 | S24 | 0.999 |
S7 | 0.968 | S25 | 0.990 |
S8 | 0.989 | S26 | 0.993 |
S9 | 0.990 | S27 | 0.999 |
S10 | 0.989 | S28 | 0.996 |
S11 | 0.998 | S29 | 0.996 |
S12 | 0.996 | S30 | 0.995 |
S13 | 0.993 | S31 | 0.989 |
S14 | 0.981 | S32 | 0.998 |
S15 | 0.972 | S33 | 0.998 |
S16 | 0.992 | S34 | 0.996 |
S17 | 0.995 | S35 | 0.992 |
S18 | 0.991 |
Compound | Linear regression equation | R2 | Linear range/(mg/L) | Intercept error/% |
---|---|---|---|---|
Mangiferin | y=3103.7x-4181.5 | 0.9998 | 5.3291-133.2276 | 1.73 |
Isomangiferin | y=2776.1x-3129.6 | 0.9998 | 4.1847-104.6170 | 1.84 |
Table 4 Linear regression equations, correlation coefficients (R2), linear ranges and intercept errors of mangiferin and isomangiferin
Compound | Linear regression equation | R2 | Linear range/(mg/L) | Intercept error/% |
---|---|---|---|---|
Mangiferin | y=3103.7x-4181.5 | 0.9998 | 5.3291-133.2276 | 1.73 |
Isomangiferin | y=2776.1x-3129.6 | 0.9998 | 4.1847-104.6170 | 1.84 |
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