Chinese Journal of Chromatography

Chinese Journal of Chromatography

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Development of On-Line Sample Preparation Coupled with Liquid Chromatography-Mass Spectrometry for
Analysis of Small Molecules in Biofluids

LIU Min, ZHAO Lixia, GUO Baoyuan, LIN Jin-Ming

  

  1. State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, the Chinese Academy of Sciences, Beijing 100085, China

  • Received:2007-08-24 Revised:1900-01-01 Online:2007-09-30 Published:1985-03-25
  • Contact: LIN Jin-Ming

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Abstract:

On-line liquid chromatography-mass spectrometry (LC-MS) is a highly sensitive, highly selective and high throughput method for the analysis of small molecules in biofluids. The developments, characterizations and applications of pre-column, on-line LC-MS method and its configuration in the recent five years are reviewed.

Key words: biofluids, liquid chromatography-mass spectrometry (LC-MS), review , small molecules, on-line solid phase extraction