Analytical methods for urinary biomarkers of human exposure to phthalates

doi:10.3724/SP.J.1123.2019.03029

Abstract

Abstract: Phthalates (PAEs) are a class of endocrine-disrupting chemicals. In recent years, the harmful effects of PAEs on human health, in particular their toxicity toward the reproductive system and development, have received significant attention because of their increasing production and usage. PAEs are ubiquitous in the environment and food products, resulting in unavoidable and long-term exposure in humans. Therefore, exposure and risk assessments of PAEs in humans are necessary. Screening and quantification of phthalate metabolites in urine is an important method for evaluating PAEs exposure, and establishing accurate analytical methods for this purpose has become a high priority. Phthalate monoesters and secondary metabolites are the most commonly targeted biomarkers of exposure to short-and long-chain PAEs, respectively. The combination of off-line or on-line solid phase extraction (SPE) with high performance liquid chromatography-tandem mass spectrometry has become the preferred method for the determination of phthalate metabolites. This paper reviews the analytical methods available for the detection of urinary phthalate metabolites and discusses the advantages, limitations, and challenges presented by each method in practical applications.

Key words: biomarkers, gas chromatography-mass spectrometry (GC-MS), liquid chromatography-tandem mass spectrometry (LC-MS/MS), phthalate exposure, review, solid phase extraction (SPE)

CLC Number:

O658

HUANG Chaonan, LI Yun, PENG Junyu, CHEN Jiping. Analytical methods for urinary biomarkers of human exposure to phthalates[J]. Chinese Journal of Chromatography, 2019, 37(8): 815-823.

References

[1] Qureshi M S, Yusoff A R B, Wirzal M D H, et al. Crit Rev Anal Chem, 2016, 46(2):146

[2] Net S, Sempere R, Delmont A, et al. Environ Sci Technol, 2015, 49(7):4019

[3] Gao D W, Wen Z D. Sci Total Environ, 2016, 541:986

[4] Clausen P A, Hansen V, Gunnarsen L, et al. Environ Sci Technol, 2004, 38(9):2531

[5] Pei J J, Sun Y H, Yin Y H. Sci Total Environ, 2018, 639:760

[6] Langer S, Beko G, Weschler C J, et al. Int J Hyg Environ Health, 2014, 217(1):78

[7] Fu P Q, Kawamura K, Barrie L A. Environ Sci Technol, 2009, 43(2):286

[8] Net S, Dumoulin D, El-Osmani R, et al. Int J Environ Res, 2014, 8(4):1159
[9] LaRocca J, Binder A M, McElrath T F, et al. Environ Health Perspect, 2016, 124(3):380

[10] Kay V R, Bloom M S, Foster W G. Crit Rev Toxicol, 2014, 44(6):467

[11] Bo C X, Yang Z F, Du Z J. Journal of Environmental Health, 2015, 32(7):647薄存香, 杨治峰, 杜忠君. 环境与健康杂志, 2015, 32(7):647
[12] Dallongeville A, Costet N, Zmirou-Navier D, et al. Indoor Air, 2016, 26(3):426

[13] Maresca M M, Hoepner L A, Hassoun A, et al. Environ Health Perspect, 2016, 124(4):514

[14] Duan Y S, Wang L, Han L P, et al. Environ Int, 2017, 109:53

[15] Colon I, Caro D, Bourdony C J, et al. Environ Health Perspect, 2000, 108(9):895
[16] Huang H B, Chen H Y, Su P H, et al. PLoS One, 2015, 10(6):13
[17] Rocha B A, Asimakopoulos A G, Barbosa F, et al. Sci Total Environ, 2017, 586:152

[18] Kumar A R, Sivaperumal P. TrAC-Trend Anal Chem, 2016, 75:151

[19] Sun J, Zhang M R, Zhang L Q, et al. Int J Environ Health Res, 2016, 26(3):306

[20] Gries W, Ellrich D, Kupper K, et al. J Chromatogr B, 2012, 908:128

[21] Wittassek M, Koch H M, Angerer J, et al. Mol Nutr Food Res, 2011, 55(1):7

[22] Silva M J, Barr D B, Reidy J A, et al. Arch Toxicol, 2003, 77(10):561

[23] Koch H M, Bolt H M, Preuss R, et al. Arch Toxicol, 2005, 79(7):367

[24] Feng Y L, Liao X J, Grenier G, et al. Anal Methods, 2015, 7(19):8048

[25] Ebrahim K, Poursafa P, Amin M M. J Sep Sci, 2017, 40(22):4403

[26] Blount B C, Milgram K E, Silva M J, et al. Anal Chem, 2000, 72(17):4127

[27] Hogberg J, Hanberg A, Berglund M, et al. Environ Health Perspect, 2008, 116(3):334

[28] Jensen M S, Norgaard-Pedersen B, Toft G, et al. Environ Health Perspect, 2012, 120(6):897

[29] Hines E P, Calafat A M, Silva M J, et al. Environ Health Perspect, 2009, 117(1):86

[30] Adachi K, Suemizu H, Murayama N, et al. Environ Toxicol Pharmacol, 2015, 39(3):1067

[31] Dimpe K M, Nomngongo P N. TrAC-Trend Anal Chem, 2016, 82:199

[32] Guo K, Li L. Anal Chem, 2010, 82(21):8789

[33] Du L P, Ma L J, Qiao Y, et al. Food Chem, 2016, 197:1200

[34] Kang L, Liu H H, Liao S C, et al. Chinese Journal of Health Laboratory Technology, 2017, 27(23):3349康莉, 刘红河, 廖仕成, 等. 中国卫生检验杂志, 2017, 27(23):3349
[35] Silva M J, Barr D B, Reidy J A, et al. Environ Health Perspect, 2004, 112(3):331

[36] Kondo F, Ikai Y, Hayashi R, et al. Bull Environ Contam Toxicol, 2010, 85(1):92

[37] Yoshida T. Biomed Chromatogr, 2017, 31(7):1
[38] Wang L Y, Zou Y, Wu P G, et al. Journal of Hygiene Research, 2017, 46(6):991王立媛, 邹艳, 吴平谷, 等. 卫生研究, 2017, 46(6):991
[39] Chen M, Tao L, Collins E M, et al. J Chromatogr B, 2012, 904:73

[40] Gao H, Xu Y Y, Sun L, et al. Chinese Journal of Chromatography, 2015, 33(6):622高慧, 许媛媛, 孙丽, 等. 色谱, 2015, 33(6):622

[41] Zhang X, Qiu T, Fu H, et al. Chinese Journal of Chromatography, 2018, 36(9):895张续, 邱天, 付慧, 等. 色谱, 2018, 36(9):895

[42] Alzaga R, Pena A, Bayona J M. J Sep Sci, 2003, 26(1/2):87
[43] Rastkari N, Ahmadkhaniha R. J Chromatogr A, 2013, 1286:22

[44] Heffernan A L, Thompson K, Eaglesham G, et al. Talanta, 2016, 151:224

[45] Sabaredzovic A, Sakhi A K, Brantsaeter A L, et al. J Chromatogr B, 2015, 1002:343

[46] Huang L F, Jia B, Jiang L, et al. J Sep Sci, 2019, 42(4):843

[47] Wang C, Li M, Xu H, et al. J Chromatogr A, 2014, 1343:195

[48] Preuss R, Koch H M, Angerer J. J Chromatogr B, 2005, 816(1/2):269
[49] Kato K, Silva M J, Needham L L, et al. Anal Chem, 2005, 77(9):2985

[50] Herrero L, Calvarro S, Fernandez M A, et al. Anal Chim Acta, 2015, 853:625

[51] Fernandez M A M, Andre L C, Cardeal Z L. J Chromatogr A, 2017, 1481:31

[52] Kim M, Song N R, Choi J H, et al. Sci Total Environ, 2014, 470/471:1408
[53] Kim S H, On J W, Pyo H, et al. PLoS One, 2018, 13(11):1
[54] Bamai Y A, Araki A, Kawai T, et al. Int J Hyg Environ Health, 2015, 218(5):461

[55] Inoue K, Kawaguchi M, Okada F, et al. Anal Bioanal Chem, 2003, 375(4):527

[56] Liou S H, Yang G C, Wang C L, et al. J Hazard Mater, 2014, 277:169

[57] Miao H J, Huang Y, Ma C, et al. J AOAC Int, 2019, 102(1):271

[58] Zhu Y S, Wan Y J, Li Y Y, et al. Environ Int, 2016, 88:67

[59] Silva M J, Samandar E, Preau J L, et al. J Chromatogr B, 2007, 860(1):106

[60] Wang H X, Wang B, Zhou Y, et al. Anal Bioanal Chem, 2013, 405(12):4313

[61] Johns L E, Cooper G S, Galizia A, et al. Environ Int, 2015, 85:27

[62] Schantz M M, Benner B A, Heckert N A, et al. Anal Bioanal Chem, 2015, 407(11):2945

[63] Hart L B, Beckingham B, Wells R, et al. GeoHealth, 2018, 2:313

[64] Teitelbaum S L, Britton J A, Calafat A M, et al. Environ Res, 2008, 106(2):257
[65] Sakhi A K, Sabaredzovic A, Cequier E, et al. Sci Total Environ, 2017, 599:1984