Three chiral metal organic frameworks used as stationary phases for the separation of racemates by open tubular capillary electrochromatography

doi:10.3724/SP.J.1123.2016.06040

Abstract

Abstract:

Metal organic frameworks (MOFs) have attracted a tremendous attention in enantioselective catalysis and separation due to their unusual properties such as rich topologies, high surface area, good stability, permanent micropocity, availability of outer-surface modification and so on. In this study, three chiral MOFs, Co₂(D-cam)₂(TMDPy) (abbreviated as MOF 1),[Cd(D-cam)(tmdpy)]·2H₂O (abbreviated as MOF 2) and[Co_0.5Zn_0.5(L-Tyr)]_n(L-tyrCo/Zn) (abbreviated as MOF 3) were synthesized and respectively used as chiral stationary phases in open tubular capillary electrochromatography (OT-CEC). The three MOFs were characterized by powder X-ray diffraction (XRD) and scanning electron microscope (SEM). The three MOFs coated columns were developed using a simple procedure via MOFs post-coated on the sodium silicate layer. The experimental results showed that the three MOFs based chiral columns had better recognition ability toward some racemates. The baseline separation of furoin was achieved on the MOF 1 coated column with high resolution of more than 2.10. The influences of pH, organic modifier content and buffer concentration on the separation were investigated. The results demonstrated that chiral MOFs were promising for enantioseparation in CEC.

Key words: capillary electrochromatography (CEC), chiral open tubular capillary column, chiral separation, metal organic frameworks (MOFs)

CLC Number:

O658

ZHU Pengjing, TAO Yong, ZHANG Junhui, ZI Min, YUAN Liming. Three chiral metal organic frameworks used as stationary phases for the separation of racemates by open tubular capillary electrochromatography[J]. Chinese Journal of Chromatography, 2016, 34(12): 1219-1227.

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