Application advances of microfluidic chips for sorting circulating tumor cells in clinical samples

doi:10.3724/SP.J.1123.2016.09005

Abstract

Abstract:

Cancer is becoming a common disease threatening seriously to the human health. Circulating tumor cells (CTCs) is a kind of cancer cells released from tumors and circulates with bloodstream. It is gradually discovered of the potential value of CTCs in diagnosis of cancer in initial stage, individual treatment and research of metastasis mechanism. However, it is a very challenge task for sorting the extremely few CTCs in blood. Microfluidic chip, a miniaturized, high-throughput and integrated platform, shows the unique advantages in the study of CTCs. With the progress of the research, the technology is no longer limited to the development of sorting method based on model samples, but scientists pay more attention to the analysis of clinical samples. To the best of our knowledge, there has been no paper summing up the progress of microfluidic chip techniques applied to the analysis of clinical samples recently. This review focuses on those microfluidic techniques that have been applied to sorting CTCs from the blood of cancer patients. Meanwhile, we predict the trends of sorting CTCs in clinical samples using microfluidic chip technology.

Key words: circulating tumor cells (CTCs), clinical samples, microfluidic chip, review, sorting

CLC Number:

O658

BAO James Jianmin, WANG Dandan, LI Youxin. Application advances of microfluidic chips for sorting circulating tumor cells in clinical samples[J]. Chinese Journal of Chromatography, 2017, 35(1): 129-137.

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