Preparation of macrocycle antibiotic chiral stationary phases by wrapping with a net in high performance liquid chromatography

doi:10.3724/SP.J.1123.2018.08035

Abstract

Abstract:

Vancomycin and teicoplanin are glycopeptide macrocyclic antibiotics with three-dimensional ring structures and multiple chiral centers. They are commonly used chiral recognition materials in enantioseparation by high-performance liquid chromatography. In this study, six chiral stationary phases wrapped with a net on silica gels were prepared by interfacial polymerization using vancomycin and teicoplanin as chiral selectors, piperazine as a monomer, 4,4'-diphenylmethane diisocyanate (MDI), 1,6-hexamethylene diisocyanate (HDI), and 2,4-toluene diisocyanate (TDI) as crosslinker. The fabricated chiral columns were used for enantioseparations. Compared to the crosslinked and commercial columns composed of vancomycin and teicoplanin, the columns wrapped with a net exhibited complementarity for the optical resolutions.

Key words: chiral stationary phase, high performance liquid chromatography (HPLC), interfacial polymerization, macrocycle antibiotic

CLC Number:

O658

HE Yijuan, LI Keli, LI Qian, ZHANG Peng, AI Ping, YUAN Liming. Preparation of macrocycle antibiotic chiral stationary phases by wrapping with a net in high performance liquid chromatography[J]. Chinese Journal of Chromatography, 2019, 37(4): 383-391.

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