Drug target deconvolution by chemical proteomics

doi:10.3724/SP.J.1123.2019.12014

Abstract

Abstract:

Drug target identification can help establish the association between drug activity and phenotypes, elucidate the mechanism of action, discover off-target effects and drug resistance mechanisms, discover new targets for therapeutic drugs, and predict possible side effects and toxicity at an early stage of drug discovery, thereby reducing the risk of failure in drug development. Although rapid progress has been made in scientific discoveries and technological advancements, the identification of drug targets is still a daunting task. Herein, the research progress in drug target identification during the past decade, especially novel technologies without chemical labeling, have been reviewed.

Key words: drug target identification, chemical proteomics, review

GONG Li, KANG Jingwu. Drug target deconvolution by chemical proteomics[J]. Chinese Journal of Chromatography, 2020, 38(8): 877-879.

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