Chinese Journal of Chromatography

Chinese Journal of Chromatography

• “多维色谱”专栏 • Previous Articles     Next Articles

Multidimensional Separations Used in Pharmaceutical and Biological Fields

TIAN Jing1,2, LU Xin1, YANG Jun1, KONG Hongwei1, WANG Yuan1, ZHAO Xinjie1, Guowang xu   

  1. 1. National Chromatographic R. &A. Center, Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116011, China; 2. Analysis Center,　Dalian Institute of Light Industry, Dalian 116001,China; 3. College of Chemistry, Jilin University, Changchun 130021, China
  • Received:2004-07-30 Revised:1900-01-01 Online:2005-01-30 Published:1989-03-25
  • Contact: Guowang xu

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Abstract: A review of multidimensional separations such as comprehensive two-dimensional gas chromatography (GC×GC), comprehensive two-dimensional high performance liquid chromatography (HPLC×HPLC) and their applications in pharmaceutical and biological fields is presented with 71 references. A single CO2 cryo-jet loop modulator was developed for GC×GC and it can be used to modulate compounds higher than C6 effectively. Comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry (GC×GC/TOF-MS) analyses of traditional Chinese medicine volatile oils such as Pogostemon cablin Benth (Cablin Patchouli), Forsythia suspensa (Thunb.) Vahl and Zedoary were reported also. As an emerging technology, multidimensional separations hold the promise and play an important role in the future pharmaceutical and biological fields.

Key words: chromatography, biological, hyphenation techniques, pharmaceutical, review , multidimensional separations