Chinese Journal of Chromatography

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Developments and applications of multidimensional liquid chromatography in proteomics

ZHU Guijie, LIANG Zhen, ZHANG Lihua*, ZHANG Yukui   

  1. National Chromatographic R. &A. Center, CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, the Chinese Academy of Sciences, Dalian 116023, China
  • Received:2009-08-04 Revised:2009-09-02 Online:2009-09-30 Published:1982-03-25
  • Contact: ZHANG Lihua

Abstract: This review summarizes the recent developments of multidimensional liquid chromatography (MDLC) techniques, and their applications in proteomics study, including expression profiling, post-translational modification, quantitative analysis, and so forth. In addition, the prospect and further developments of MDLC are discussed.

Key words: proteomics, review , multidimensional liquid chromatography