Abstract:

A method for the determination of citric acid in multi-matrix by liquid phase chromatography with liquid phase microextraction (LPME) as sample-preparation technique is introduced. The method integrates extraction, enrichment and clean-up into a single step. It is a very fast, effective and virtually “green” sample-preparation technique, which provided a good linear range (0.7-600 μg/mL) with r2=0.9995, a low detection limit (0.27 μg/mL, S/N=3) and a satisfactory relative standard deviation (RSD<5%).

Key words: citric acid, high performance liquid chromatography (HPLC), hollow fiber, multi-matrix , liquid phase microextraction