Chinese Journal of Chromatography ›› 2018, Vol. 36 ›› Issue (8): 716-722.DOI: 10.3724/SP.J.1123.2018.03033

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Preparation of magnetic surface molecularly imprinted polymers for melamine and its application in milk samples

SUN Zhi'an, QI Yuxia, WANG Xia, ZHOU Yanqiang, GONG Bolin   

  1. School of Chemistry and Chemical Engineering, North Minzu University, Yinchuan 750021, China
  • Received:2018-03-27 Online:2018-08-08 Published:2014-06-28
  • Supported by:

    National Natural Science Foundation of China (Nos.21565001, 31271868).


By using melamine (MEL) as the template molecule, magnetic surface molecularly imprinted polymers (MMIPs) were prepared. Methacrylic acid (MAA) was chosen as the functional monomer, and ethyleneglycol dimethacrylate (EGDMA) was chosen as the cross-linker, and Fe3O4@SiO2 was used as the magnetic supporter. Transmission electron microscope (TEM), thermogravimetric analysis (TGA), Fourier transform infrared (FT-IR) analysis and a vibrating sample magnetometer (VSM) were used to characterize the polymers. An imprinted polymer layer was found on the surface of the Fe3O4@SiO2 nanomaterials. MMIPs were applied to extract and enrich melamine in milk samples. The specific recognition capability of the material was confirmed by high performance liquid chromatographic (HPLC) analysis. Thus, a simple and selective method was successfully established using MMIPs as sorbents to detect melamine in milk with satisfactory results.

Key words: Fe3O4 nanoparticle, high performance liquid chromatography (HPLC), magnetic surface molecularly imprinted polymers (MMIPs), melamine, preparation, recognition character

CLC Number: