Chinese Journal of Chromatography ›› 2016, Vol. 34 ›› Issue (1): 113-118.DOI: 10.3724/SP.J.1123.2015.08001

• Articles • Previous Articles    

Single-handed helical framework material [{Cu(sala)}n] incorporated peramylated β-cyclodextrin for improving gas chromatography enantioseparation

XIE Shengming1, LIU Hong2, YANG Jiangrong3, AI Ping1, YUAN Liming1   

  1. 1. School of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China;
    2. Chuxiong Institute for Food and Drug Control, Chuxiong 675000, China;
    3. Dehong Vocational College, Dehong 678400, China
  • Received:2015-08-01 Online:2016-01-08 Published:2012-08-01
  • Supported by:

    National Natural Science Foundation (21275126, 21365024); Yunnan Province's Basic Research Program (2013FB035).

Abstract:

Metal-organic frameworks (MOFs) as a new generation of functional molecular materials, have broad application prospects in enantioselective catalysis and chiral separation areas due to their unusual properties, such as high surface area, rich topologies, permanent microporous, availability of outer-surface modification and so on. A single-handed helical three-dimensional metal-organic framework material [{Cu(sala)}n] (H2sala=N-(2-hydroxybenzyl)-L-alanine) was incorporated with peramylated β-cyclodextrin for the preparation of novel capillary gas chromatography stationary phase. To investigate whether the use of a chiral MOF can enhance enantioseparation on peramylated β-cyclodextrin, three chiral columns were fabricated using different stationary phases for comparison, including column A ([{Cu(sala)}n]), column B (peramylated β-cyclodextrin) and column C ([{Cu(sala)}n]+peramylated β-cyclodextrin). The results of comparing the resolving abilities of the three columns for the same chiral compounds demonstrated that column C showed better enantioselectivity and higher resolution. The use of MOF [{Cu(sala)}n] can improve enantioseparation on peramylated β-cyclodextrin.

Key words: capillary column, chiral separation, gas chromatography (GC), metal-organic frameworks (MOFs), peramylated β-cyclodextrin, stationary phase

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